1hy3 Summary

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CRYSTAL STRUCTURE OF HUMAN ESTROGEN SULFOTRANSFERASE V269E MUTANT IN THE PRESENCE OF PAPS

The structure was published by Pedersen, L.C., Petrotchenko, E., Shevtsov, S., and Negishi, M., in 2002 in a paper entitled "Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ESTROGEN SULFOTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ESTROGEN SULFOTRANSFERASE P49888 (1-294) (ST1E1_HUMAN)search Homo sapienssearch 100% 294 97%
B ESTROGEN SULFOTRANSFERASE P49888 (1-294) (ST1E1_HUMAN)search Homo sapienssearch 100% 294 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49888 (1 - 294) ESTROGEN SULFOTRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49888) PAPS sulfotransferasesearch P-loop containing nucleotide triphosphate hydrolasessearch PF00685: Sulfotransferase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49888) xenobiotic metabolic processsearch sulfationsearch female pregnancysearch estrogen metabolic processsearch steroid metabolic processsearch small molecule metabolic processsearch 3'-phosphoadenosine 5'-phosphosulfate metabolic processsearch steroid sulfotransferase activitysearch sulfotransferase activitysearch estrone sulfotransferase activitysearch transferase activitysearch lipid bindingsearch steroid bindingsearch flavonol 3-sulfotransferase activitysearch cytoplasmsearch cytosolsearch nucleussearch nuclear membranesearch

Chain InterPro annotation
A, B Sulfotransferase domainsearch P-loop containing nucleoside triphosphate hydrolasesearch