› 1hvn

Solution NMR

ZINC-AND SEQUENCE-DEPENDENT BINDING TO NUCLEIC ACIDS BY THE N-TERMINAL ZINC FINGER DOMAIN OF THE HIV-1 NUCLEOCAPSID PROTEIN: NMR STRUCTURE OF THE COMPLEX WITH THE PSI-SITE ANALOG, D/ACGCC

Released:
DOI: 10.2210/pdb1hvn/pdb
PDB entry 1hvn coloured by chain, ensemble of 15 models, front view.
PDB entry 1hvn coloured by chain, ensemble of 15 models, side view.
PDB entry 1hvn coloured by chain, ensemble of 15 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Zinc- and sequence-dependent binding to nucleic acids by the N-terminal zinc finger of the HIV-1 nucleocapsid protein: NMR structure of the complex with the Psi-site analog, dACGCC.
South TL, Summers MF
Protein Sci 2 3-19 (1993)
PMID: 8443588

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Nucleocapsid protein p7 Chain: E
Molecule details ›
Chain: E
Length: 18 amino acids
Theoretical weight: 2.01 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q70622 (Residues: 390-407; Coverage: 4%)
Gene name: gag
Sequence domains: Zinc knuckle
DNA (5'-D(P*AP*CP*GP*CP*C)-3') Chain: D
Molecule details ›
Chain: D
Length: 5 nucleotides
Theoretical weight: 1.47 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

10 review citations

HIV-1 gag proteins: diverse functions in the virus life cycle.
Freed EO. (1998)
9 more

1 mention without citation

Native, sequential protein folding via anchored N and C protein termini.
Alberti S. (2016)