› 1hvg

X-ray diffraction
3Å resolution

STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER

Released:
DOI: 10.2210/pdb1hvg/pdb
PDB entry 1hvg coloured by chain, front view.
PDB entry 1hvg coloured by chain, side view.
PDB entry 1hvg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter.
Burger A, Voges D, Demange P, Perez CR, Huber R, Berendes R
J Mol Biol 237 479-99 (1994)
PMID: 8151707

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A5 Chain: A
Molecule details ›
Chain: A
Length: 319 amino acids
Theoretical weight: 35.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08758 (Residues: 2-320; Coverage: 100%)
Gene names: ANX5, ANXA5, ENX2, PP4
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: R3
Unit cell:
a: 156.9Å b: 156.9Å c: 36.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.199 not available
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Annexin II tetramer: structure and function.
Waisman DM. (1995)
8 more