1hum Summary

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SOLUTION STRUCTURE OF THE CHEMOKINE HMIP-1BETA(SLASH)ACT-2 BY MULTI-DIMENSIONAL NMR: A NOVEL CHEMOKINE DIMER

The structure was published by Lodi, P.J., Garrett, D.S., Kuszewski, J., et al., Leonard, W.J., Gronenborn, A.M., and Clore, G.M., in 1994 in a paper entitled "High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1994.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of HUMAN MACROPHAGE INFLAMMATORY PROTEIN 1 BETA.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HUMAN MACROPHAGE INFLAMMATORY PROTEIN 1 BETA P13236 (24-92) (CCL4_HUMAN)search Homo sapienssearch 99% 69 100%
B HUMAN MACROPHAGE INFLAMMATORY PROTEIN 1 BETA P13236 (24-92) (CCL4_HUMAN)search Homo sapienssearch 99% 69 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P13236 (24 - 92) HUMAN MACROPHAGE INFLAMMATORY PROTEIN 1 BETA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P13236) Interleukin 8-like chemokinessearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search PF00048: Small cytokines (intecrine/chemokine), interleukin-8 likesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P13236) positive regulation of natural killer cell chemotaxissearch positive regulation of calcium-mediated signalingsearch immune responsesearch cell chemotaxissearch signal transductionsearch negative regulation by host of viral transcriptionsearch cellular component movementsearch inflammatory responsesearch cell adhesionsearch chemotaxissearch response to toxic substancesearch positive regulation of calcium ion transportsearch establishment or maintenance of cell polaritysearch cell-cell signalingsearch response to virussearch identical protein bindingsearch CCR5 chemokine receptor bindingsearch chemokine activitysearch CCR1 chemokine receptor bindingsearch cytokine activitysearch extracellular regionsearch extracellular spacesearch

Chain InterPro annotation
A, B CC chemokine, conserved sitesearch Chemokine interleukin-8-like domainsearch