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DIFFERENCES IN ANIONIC INHIBITION OF HUMAN CARBONIC ANHYDRASE I REVEALED FROM THE STRUCTURES OF IODIDE AND GOLD CYANIDE INHIBITOR COMPLEXES

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: one-carbon metabolic process
Cellular component: extracellular exosome

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EC 4.2.1.69: Cyanamide hydratase

Reaction catalysed:
Urea = cyanamide + H(2)O
Systematic name:
Urea hydro-lyase (cyanamide-forming)
Alternative Name(s):
  • Urea hydro-lyase

EC 4.2.1.1: Carbonic anhydrase

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O
Systematic name:
Carbonic acid hydro-lyase (carbon-dioxide-forming)
Alternative Name(s):
  • Anhydrase
  • Carbonate anhydrase
  • Carbonate dehydratase
  • Carbonate hydro-lyase
  • Carbonic acid anhydrase
  • Carbonic anhydrase A
  • Carbonic dehydratase
  • Carboxyanhydrase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00194
Domain description: Eukaryotic-type carbonic anhydrase
Occurring in:
  1. Carbonic anhydrase 1
The deposited structure of PDB entry 1huh contains 1 copy of Pfam domain PF00194 (Eukaryotic-type carbonic anhydrase) in Carbonic anhydrase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001148
Domain description: Alpha carbonic anhydrase domain
Occurring in:
  1. Carbonic anhydrase 1
IPR036398
Domain description: Alpha carbonic anhydrase domain superfamily
Occurring in:
  1. Carbonic anhydrase 1
IPR018338
Domain description: Carbonic anhydrase, alpha-class, conserved site
Occurring in:
  1. Carbonic anhydrase 1
IPR023561
Domain description: Carbonic anhydrase, alpha-class
Occurring in:
  1. Carbonic anhydrase 1

Structure domain

CATH CATH domain
3.10.200.10
Class: Alpha Beta
Architecture: Roll
Topology: Carbonic Anhydrase II
Homology: Alpha carbonic anhydrase
Occurring in:
  1. Carbonic anhydrase 1
The deposited structure of PDB entry 1huh contains 1 copy of CATH domain 3.10.200.10 (Carbonic Anhydrase II) in Carbonic anhydrase 1. Showing 1 copy in chain A.
SCOP SCOP annotation
51070
Class: All beta proteins
Fold: Carbonic anhydrase
Superfamily: Carbonic anhydrase
Occurring in:
  1. Carbonic anhydrase 1
The deposited structure of PDB entry 1huh contains 1 copy of SCOP domain 51070 (Carbonic anhydrase) in Carbonic anhydrase 1. Showing 1 copy in chain A.

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