1huc Summary

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THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY

The structure was published by Musil, D., Zucic, D., Turk, D., et al., Towatari, T., Katunuma, N., and Bode, W., in 1991 in a paper entitled "The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CATHEPSIN B.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CATHEPSIN B P07858 (80-126) (CATB_HUMAN)search Homo sapienssearch < 90% 47 100%
C CATHEPSIN B P07858 (80-126) (CATB_HUMAN)search Homo sapienssearch < 90% 47 100%
B CATHEPSIN B P07858 (129-333) (CATB_HUMAN)search Homo sapienssearch < 90% 205 100%
D CATHEPSIN B P07858 (129-333) (CATB_HUMAN)search Homo sapienssearch < 90% 205 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07858 (80 - 126) CATHEPSIN B Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C Papain-likesearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Papain family cysteine proteasesearch
B, D Papain-likesearch Cysteine proteinasessearch Papain family cysteine proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, C (P07858) cysteine-type peptidase activitysearch proteolysissearch
B, D (P07858) cysteine-type peptidase activitysearch proteolysissearch

Chain InterPro annotation
A, C Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch
B, D Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch