1hto Summary

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CRYSTALLOGRAPHIC STRUCTURE OF A RELAXED GLUTAMINE SYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS

The structure was published by Gill, H.S., Pfluegl, G.M., and Eisenberg, D., in 2002 in a paper entitled "Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of GLUTAMINE SYNTHETASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
B GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
C GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
D GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
E GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
F GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
G GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
H GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
I GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
J GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
K GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
L GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
M GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
N GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
O GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
P GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
Q GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
R GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
S GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
T GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
U GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
V GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
W GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%
X GLUTAMINE SYNTHETASE P9WN39 (2-478) (GLNA1_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 477 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WN39 (2 - 478) GLUTAMINE SYNTHETASE Mycobacterium tuberculosis

Chain Structural classification (SCOP) Structural classification (CATH)
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (P9WN39) Glutamine synthetase, N-terminal domainsearch, Glutamine synthetase catalytic domainsearch Creatine Kinase; Chainsearch, Ubiquitin-like (UB roll)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (P9WN39) glutamate-ammonia ligase activitysearch ATP bindingsearch catalytic activitysearch ligase activitysearch nucleotide bindingsearch nitrogen compound metabolic processsearch nitrogen fixationsearch growthsearch glutamine biosynthetic processsearch cytoplasmsearch cytosolsearch plasma membranesearch cell wallsearch extracellular regionsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X Glutamine synthetase class-I, adenylation sitesearch Glutamine synthetase type Isearch Glutamine synthetase, catalytic domainsearch Glutamine synthetase, beta-Graspsearch Glutamine synthetase/guanido kinase, catalytic domainsearch Glutamine synthetase, N-terminal conserved sitesearch Glutamine synthetase, glycine-rich sitesearch