1ht8 Summary



The structure was published by Selinsky, B.S., Gupta, K., Sharkey, C.T., and Loll, P.J., in 2001 in a paper entitled "Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.69 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROSTAGLANDIN H2 SYNTHASE-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROSTAGLANDIN H2 SYNTHASE-1 P05979 (33-583) (PGH1_SHEEP)search Ovis ariessearch 96% 551 100%
B PROSTAGLANDIN H2 SYNTHASE-1 P05979 (33-583) (PGH1_SHEEP)search Ovis ariessearch 96% 551 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (33 - 583) PROSTAGLANDIN H2 SYNTHASE-1 Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P05979) inflammatory responsesearch regulation of blood pressuresearch prostaglandin biosynthetic processsearch fatty acid biosynthetic processsearch cyclooxygenase pathwaysearch response to oxidative stresssearch oxidation-reduction processsearch prostaglandin metabolic processsearch fatty acid metabolic processsearch lipid metabolic processsearch membranesearch endoplasmic reticulumsearch intracellular membrane-bounded organellesearch integral component of membranesearch endoplasmic reticulum membranesearch cytoplasmsearch organelle membranesearch nucleussearch oxidoreductase activitysearch peroxidase activitysearch heme bindingsearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search