 |
PDBe Entry: 1hq5 
CRYSTAL STRUCTURE OF THE BINUCLEAR MANGANESE METALLOENZYME ARGINASE COMPLEXED WITH S-(2-BORONOETHYL)-L-CYSTEINE, AN L-ARGININE ANALOGUE
 |
HYDROLASE
|
|
X-RAY DIFFRACTION
|
|
Resolution: 2.3 Å, R-factor: 15.8%, Free R-factor: 19.4%, Spacegroup: P 3
|
|
04/04/2001, deposition: 14/12/2000, last revision: 24/02/2009
|
|
Kim, N.N.; Cox, J.D.; Baggio, R.F.; Emig, F.A.; Mistry, S.K.; Harper, S.L.; Speicher, D.W.; Morris Jr., S.M.; Ash, D.E.; Traish, A.; Christianson, D.W.
|
Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum.
BIOCHEMISTRY vol:40, pag:2678-2688 (2001) [PubMed ID 11258879 ]
|
|
BINUCLEAR MANGANESE CLUSTER, BORONIC ACID INHIBITOR, PERFECTLY TWINNED CRYSTAL, HYDROLASE
|
|
3.5.3.1 ExPASy BRENDA (A B)
|
|
Rattus norvegicus(Norway rat) 10116(A B)
|
|
Arginase-1 (EC 3.5.3.1) (Type I arginase) (Liver-type arginase) P07824 (A B)
|
|
A, B
|
|
1d3v, 1rla
|
| A, B |
ARGINASE 1 |
Protein |
P07824 (ARGI1_RAT)
|
323 |
95% |
|
| A, B |
MANGANESE (II) ION |
MN
|
| A, B |
S-2-(BORONOETHYL)-L-CYSTEINE |
S2C
|
|
|
