› 1hpl

X-ray diffraction
2.3Å resolution

HORSE PANCREATIC LIPASE. THE CRYSTAL STRUCTURE AT 2.3 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1hpl/pdb
PDB entry 1hpl coloured by chain, front view.
PDB entry 1hpl coloured by chain, side view.
PDB entry 1hpl coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Horse pancreatic lipase. The crystal structure refined at 2.3 A resolution.
Bourne Y, Martinez C, Kerfelec B, Lombardo D, Chapus C, Cambillau C
J Mol Biol 238 709-32 (1994)
PMID: 8182745

Function and Biology Details

Reaction catalysed: 
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151362 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pancreatic triacylglycerol lipase Chains: A, B
Molecule details ›
Chains: A, B
Length: 449 amino acids
Theoretical weight: 49.76 KDa
Source organism: Equus caballus
Expression system: Not provided
UniProt:
  • Canonical: P29183 (Residues: 13-461; Coverage: 100%)
Gene name: PNLIP
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 79.8Å b: 97.2Å c: 145.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.159 not available
Expression system: Not provided

Quick links

Citations

7 review citations

The triglyceride lipases of the pancreas.
Lowe ME. (2002)
6 more

9 mentions without citation

Recognition of functional sites in protein structures.
Shulman-Peleg et al. (2004)
8 more