› 1hls

Solution NMR

NMR STRUCTURE OF THE HUMAN INSULIN-HIS(B16)

Released:
DOI: 10.2210/pdb1hls/pdb
PDB entry 1hls coloured by chain, ensemble of 20 models, front view.
PDB entry 1hls coloured by chain, ensemble of 20 models, side view.
PDB entry 1hls coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structure of an engineered biologically potent insulin monomer, B16 Tyr-->His, as determined by nuclear magnetic resonance spectroscopy.
Ludvigsen S, Roy M, Thøgersen H, Kaarsholm NC
Biochemistry 33 7998-8006 (1994)
PMID: 8025104

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134182 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.41 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Saccharomyces cerevisiae

Quick links

Citations

6 review citations

Growth factor receptors: structure, mechanism, and drug discovery.
McInnes et al. (1997)
5 more

1 mention without citation

De novo molecular modeling and biophysical characterization of Manduca sexta eclosion hormone.
Hull et al. (2009)