1hkx Summary

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CRYSTAL STRUCTURE OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE

The structure was published by Hoelz, A., Nairn, A.C., and Kuriyan, J., in 2003 in a paper entitled "Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.65 Å and deposited in 2003.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 14meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
B CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
C CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
D CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
E CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
F CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
G CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
H CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
I CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
J CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
K CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
L CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
M CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%
N CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11798 (336-478) (KCC2A_MOUSE)search Mus musculussearch < 90% 147 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11798 (336 - 478) CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L, M, N Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2Asearch Nuclear Transport Factor 2; Chain: A,search Calcium/calmodulin dependent protein kinase II Associationsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D, E, F, G, H, I, J, K, L, M, N (P11798) protein phosphorylationsearch calmodulin bindingsearch calmodulin-dependent protein kinase activitysearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L, M, N Calcium/calmodulin-dependent protein kinase II, association-domainsearch Calcium/calmodulin-dependent/calcium-dependent protein kinasesearch