1hkc Summary

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RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND PHOSPHATE

The structure was published by Aleshin, A.E., Zeng, C., Bartunik, H.D., Fromm, H.J., and Honzatko, R.B., in 1998 in a paper entitled "Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of D-GLUCOSE 6-PHOSPHOTRANSFERASE. This molecule has the UniProt identifier P19367 (HXK1_HUMAN)search. The sample contained 917 residues which is 100% of the natural sequence. Out of 917 residues 899 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A D-GLUCOSE 6-PHOSPHOTRANSFERASE P19367 (1-917) (HXK1_HUMAN)search Homo sapienssearch 100% 917 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19367 (1 - 917) D-GLUCOSE 6-PHOSPHOTRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P19367) Hexokinasesearch Nucleotidyltransferase; domain 5search, Hexokinase; domain 1search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P19367) ATP bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch mannokinase activitysearch transferase activitysearch catalytic activitysearch kinase activitysearch nucleotide bindingsearch protein bindingsearch fructokinase activitysearch glucokinase activitysearch glycolytic processsearch carbohydrate metabolic processsearch metabolic processsearch carbohydrate phosphorylationsearch small molecule metabolic processsearch transmembrane transportsearch hexose transportsearch cell deathsearch glucose transportsearch glucose 6-phosphate metabolic processsearch cellular glucose homeostasissearch hexose metabolic processsearch phosphorylationsearch mitochondrial outer membranesearch mitochondrionsearch membranesearch cytosolsearch membrane raftsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch