1hkb Summary

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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN BRAIN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE AND GLUCOSE-6-PHOSPHATE

The structure was published by Aleshin, A.E., Zeng, C., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., and Honzatko, R.B., in 1998 in a paper entitled "The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of D-GLUCOSE 6-PHOSPHOTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A D-GLUCOSE 6-PHOSPHOTRANSFERASE P19367 (1-917) (HXK1_HUMAN)search Homo sapienssearch 100% 917 98%
B D-GLUCOSE 6-PHOSPHOTRANSFERASE P19367 (1-917) (HXK1_HUMAN)search Homo sapienssearch 100% 917 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19367 (1 - 917) D-GLUCOSE 6-PHOSPHOTRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P19367) Hexokinasesearch Nucleotidyltransferase; domain 5search, Hexokinase; domain 1search PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P19367) nucleotide bindingsearch catalytic activitysearch glucokinase activitysearch hexokinase activitysearch protein bindingsearch ATP bindingsearch fructokinase activitysearch kinase activitysearch transferase activitysearch phosphotransferase activity, alcohol group as acceptorsearch mannokinase activitysearch cellular glucose homeostasissearch carbohydrate metabolic processsearch glycolytic processsearch metabolic processsearch cell deathsearch hexose transportsearch glucose transportsearch phosphorylationsearch hexose metabolic processsearch small molecule metabolic processsearch carbohydrate phosphorylationsearch glucose 6-phosphate metabolic processsearch transmembrane transportsearch mitochondrionsearch mitochondrial outer membranesearch cytosolsearch membranesearch

Chain InterPro annotation
A, B Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch