1hka Summary



The structure was published by Xiao, B., Shi, G., Chen, X., Yan, H., and Ji, X., in 1999 in a paper entitled "Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE. This molecule has the UniProt identifier P26281 (HPPK_ECOLI)search. The sample contained 158 residues which is 99% of the natural sequence. Out of 158 residues 158 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE P26281 (2-159) (HPPK_ECOLI)search Escherichia coli K-12search 96% 158 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P26281) 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPKsearch Alpha-Beta Plaitssearch PF01288: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)search

Chain ID Molecular function (GO) Biological process (GO)
A (P26281) kinase activitysearch ATP bindingsearch transferase activitysearch 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activitysearch magnesium ion bindingsearch nucleotide bindingsearch tetrahydrofolate biosynthetic processsearch folic acid-containing compound biosynthetic processsearch folic acid biosynthetic processsearch phosphorylationsearch

Chain InterPro annotation
A 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPKsearch