› 1hj7

Solution NMR

NMR study of a pair of LDL receptor Ca2+ binding epidermal growth factor-like domains, 20 structures

Released:
DOI: 10.2210/pdb1hj7/pdb
PDB entry 1hj7 coloured by chain, ensemble of 20 models, front view.
PDB entry 1hj7 coloured by chain, ensemble of 20 models, side view.
PDB entry 1hj7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the LDL receptor EGF-AB pair: a paradigm for the assembly of tandem calcium binding EGF domains.
Saha S, Boyd J, Werner JM, Knott V, Handford PA, Campbell ID, Downing AK
Structure 9 451-6 (2001)
PMID: 11435110

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 8.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01130 (Residues: 314-393; Coverage: 10%)
Gene name: LDLR
Structure domains: Laminin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Structure and physiologic function of the low-density lipoprotein receptor.
Jeon et al. (2005)
6 more

1 mention without citation

Structural basis for ligand capture and release by the endocytic receptor ApoER2.
Hirai et al. (2017)