› 1hj1

X-ray diffraction
2.3Å resolution

RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PURE ANTIOESTROGEN ICI164,384

Released:
DOI: 10.2210/pdb1hj1/pdb
PDB entry 1hj1 coloured by chain, front view.
PDB entry 1hj1 coloured by chain, side view.
PDB entry 1hj1 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural insights into the mode of action of a pure antiestrogen.
Pike AC, Brzozowski AM, Walton J, Hubbard RE, Thorsell AG, Li YL, Gustafsson JA, Carlquist M
Structure 9 145-53 (2001)
PMID: 11250199

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor beta Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.69 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62986 (Residues: 255-509; Coverage: 48%)
Gene names: Erbeta, Esr2, Nr3a2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand AOE 1 x AOE
Ligand PMB 1 x PMB
Ligand NI 2 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: I212121
Unit cell:
a: 60.38Å b: 82.67Å c: 106.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.251
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Estrogen receptors: how do they signal and what are their targets.
Heldring et al. (2007)
45 more

11 mentions without citation

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database.
Wang et al. (2017)
10 more