1hig Summary

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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

The structure was published by Ealick, S.E., Cook, W.J., Vijay-Kumar, S., et al., Nagabhushan, T.L., Trotta, P.P., and Bugg, C.E., in 1991 in a paper entitled "Three-dimensional structure of recombinant human interferon-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of INTERFERON-GAMMA.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
B INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
C INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
D INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (24 - 161) INTERFERON-GAMMA Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D (P01579) Interferons/interleukin-10 (IL-10)search PF00714: Interferon gammasearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B, C, D (P01579) extracellular regionsearch extracellular spacesearch external side of plasma membranesearch interferon-gamma receptor bindingsearch cytokine activitysearch defense response to virussearch positive regulation of membrane protein ectodomain proteolysissearch cell surface receptor signaling pathwaysearch apoptotic processsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of osteoclast differentiationsearch interferon-gamma-mediated signaling pathwaysearch positive regulation of tumor necrosis factor productionsearch positive regulation of interleukin-12 biosynthetic processsearch antigen processing and presentationsearch negative regulation of smooth muscle cell proliferationsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of synaptic transmission, cholinergicsearch extrinsic apoptotic signaling pathwaysearch defense response to protozoansearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of chemokine biosynthetic processsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch humoral immune responsesearch positive regulation of mesenchymal cell proliferationsearch positive regulation of vitamin D biosynthetic processsearch negative regulation of cell proliferationsearch defense response to bacteriumsearch positive regulation of interleukin-1 beta secretionsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch negative regulation of interleukin-17 productionsearch endoplasmic reticulum unfolded protein responsesearch positive regulation of transcription from RNA polymerase II promotersearch neutrophil apoptotic processsearch regulation of immune responsesearch positive regulation of transcription, DNA-templatedsearch positive regulation of smooth muscle cell apoptotic processsearch inflammatory cell apoptotic processsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of MHC class II biosynthetic processsearch adaptive immune responsesearch regulation of transcription, DNA-templatedsearch response to drugsearch positive regulation of interleukin-12 productionsearch cellular component movementsearch positive regulation of T cell proliferationsearch cellular response to interleukin-18search regulation of insulin secretionsearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of isotype switching to IgG isotypessearch cellular response to lipopolysaccharidesearch neutrophil chemotaxissearch cell cycle arrestsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch negative regulation of myelinationsearch regulation of the force of heart contractionsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of killing of cells of other organismsearch positive regulation of neuron differentiationsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch cytokine-mediated signaling pathwaysearch positive regulation of interleukin-23 productionsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch protein import into nucleus, translocationsearch negative regulation of growth of symbiont in hostsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch response to virussearch positive regulation of cell adhesionsearch regulation of growthsearch regulation of interferon-gamma-mediated signaling pathwaysearch immune responsesearch

Chain InterPro annotation
A, B, C, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch