1hig Summary

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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

The structure was published by Ealick, S.E., Cook, W.J., Vijay-Kumar, S., et al., Nagabhushan, T.L., Trotta, P.P., and Bugg, C.E., in 1991 in a paper entitled "Three-dimensional structure of recombinant human interferon-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of INTERFERON-GAMMA.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
B INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
C INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
D INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (24 - 161) INTERFERON-GAMMA Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D (P01579) Interferons/interleukin-10 (IL-10)search PF00714: Interferon gammasearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P01579) regulation of neuronal action potentialsearch positive regulation of interleukin-12 productionsearch movement of cell or subcellular componentsearch regulation of insulin secretionsearch positive regulation of tumor necrosis factor productionsearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of cell proliferationsearch neutrophil chemotaxissearch positive regulation of nitric oxide biosynthetic processsearch defense response to protozoansearch cell cycle arrestsearch regulation of hepatocyte proliferationsearch regulation of the force of heart contractionsearch negative regulation of transcription from RNA polymerase II promotersearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of MHC class II biosynthetic processsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of T cell proliferationsearch protein import into nucleus, translocationsearch cytokine-mediated signaling pathwaysearch positive regulation of interleukin-23 productionsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch response to virussearch humoral immune responsesearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of synaptic transmission, cholinergicsearch adaptive immune responsesearch regulation of growthsearch regulation of interferon-gamma-mediated signaling pathwaysearch defense response to virussearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of killing of cells of other organismsearch positive regulation of cell adhesionsearch neutrophil apoptotic processsearch antigen processing and presentationsearch immune responsesearch negative regulation of smooth muscle cell proliferationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of neuron differentiationsearch regulation of immune responsesearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch extrinsic apoptotic signaling pathwaysearch apoptotic processsearch cellular response to interleukin-18search positive regulation of interleukin-6 biosynthetic processsearch positive regulation of membrane protein ectodomain proteolysissearch cell surface receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch sensory perception of mechanical stimulussearch interferon-gamma-mediated signaling pathwaysearch positive regulation of interleukin-1 beta secretionsearch positive regulation of osteoclast differentiationsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of chemokine biosynthetic processsearch response to drugsearch negative regulation of cell proliferationsearch defense response to bacteriumsearch inflammatory cell apoptotic processsearch endoplasmic reticulum unfolded protein responsesearch negative regulation of growth of symbiont in hostsearch regulation of transcription, DNA-templatedsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of interleukin-17 productionsearch positive regulation of isotype switching to IgG isotypessearch negative regulation of epithelial cell differentiationsearch negative regulation of myelinationsearch positive regulation of mesenchymal cell proliferationsearch extracellular spacesearch extracellular regionsearch external side of plasma membranesearch cytokine activitysearch interferon-gamma receptor bindingsearch

Chain InterPro annotation
A, B, C, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch