1hig Summary

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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

The structure was published by Ealick, S.E., Cook, W.J., Vijay-Kumar, S., et al., Nagabhushan, T.L., Trotta, P.P., and Bugg, C.E., in 1991 in a paper entitled "Three-dimensional structure of recombinant human interferon-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of INTERFERON-GAMMA.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
B INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
C INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
D INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (24 - 161) INTERFERON-GAMMA Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D (P01579) Interferons/interleukin-10 (IL-10)search PF00714: Interferon gammasearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P01579) apoptotic processsearch regulation of transcription, DNA-templatedsearch defense response to virussearch neutrophil apoptotic processsearch sensory perception of mechanical stimulussearch positive regulation of membrane protein ectodomain proteolysissearch cell surface receptor signaling pathwaysearch extrinsic apoptotic signaling pathwaysearch interferon-gamma-mediated signaling pathwaysearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch negative regulation of myelinationsearch positive regulation of T cell proliferationsearch neutrophil chemotaxissearch positive regulation of interleukin-1 beta secretionsearch negative regulation of smooth muscle cell proliferationsearch positive regulation of neuron differentiationsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of tumor necrosis factor productionsearch positive regulation of chemokine biosynthetic processsearch cell cycle arrestsearch positive regulation of cell adhesionsearch cellular response to interleukin-18search humoral immune responsesearch regulation of the force of heart contractionsearch negative regulation of cell proliferationsearch negative regulation of transcription from RNA polymerase II promotersearch negative regulation of epithelial cell differentiationsearch negative regulation of interleukin-17 productionsearch positive regulation of interleukin-12 productionsearch regulation of hepatocyte proliferationsearch response to drugsearch negative regulation of growth of symbiont in hostsearch positive regulation of mesenchymal cell proliferationsearch positive regulation of vitamin D biosynthetic processsearch regulation of immune responsesearch regulation of interferon-gamma-mediated signaling pathwaysearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of smooth muscle cell apoptotic processsearch defense response to bacteriumsearch regulation of insulin secretionsearch negative regulation of growth of symbiont involved in interaction with hostsearch defense response to protozoansearch positive regulation of cell proliferationsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch cellular component movementsearch positive regulation of MHC class II biosynthetic processsearch regulation of growthsearch adaptive immune responsesearch positive regulation of interleukin-6 biosynthetic processsearch inflammatory cell apoptotic processsearch response to virussearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of synaptic transmission, cholinergicsearch positive regulation of nitric oxide biosynthetic processsearch cellular response to lipopolysaccharidesearch positive regulation of killing of cells of other organismsearch positive regulation of transcription, DNA-templatedsearch antigen processing and presentationsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch endoplasmic reticulum unfolded protein responsesearch regulation of neuronal action potentialsearch cytokine-mediated signaling pathwaysearch positive regulation of interleukin-23 productionsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch protein import into nucleus, translocationsearch immune responsesearch positive regulation of osteoclast differentiationsearch positive regulation of isotype switching to IgG isotypessearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch cytokine activitysearch interferon-gamma receptor bindingsearch

Chain InterPro annotation
A, B, C, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch