1hig Summary

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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

The structure was published by Ealick, S.E., Cook, W.J., Vijay-Kumar, S., et al., Nagabhushan, T.L., Trotta, P.P., and Bugg, C.E., in 1991 in a paper entitled "Three-dimensional structure of recombinant human interferon-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of INTERFERON-GAMMA.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
B INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
C INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
D INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (24 - 161) INTERFERON-GAMMA Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D (P01579) Interferons/interleukin-10 (IL-10)search PF00714: Interferon gammasearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P01579) negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of T cell proliferationsearch regulation of transcription, DNA-templatedsearch negative regulation of growth of symbiont in hostsearch humoral immune responsesearch positive regulation of killing of cells of other organismsearch inflammatory cell apoptotic processsearch positive regulation of transcription, DNA-templatedsearch defense response to protozoansearch cytokine-mediated signaling pathwaysearch cellular response to lipopolysaccharidesearch positive regulation of neuron differentiationsearch positive regulation of interleukin-23 productionsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch protein import into nucleus, translocationsearch positive regulation of interleukin-12 productionsearch positive regulation of cell adhesionsearch adaptive immune responsesearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of MHC class II biosynthetic processsearch extrinsic apoptotic signaling pathwaysearch positive regulation of interleukin-12 biosynthetic processsearch regulation of immune responsesearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch negative regulation of smooth muscle cell proliferationsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of osteoclast differentiationsearch positive regulation of membrane protein ectodomain proteolysissearch cell surface receptor signaling pathwaysearch apoptotic processsearch interferon-gamma-mediated signaling pathwaysearch positive regulation of interleukin-1 beta secretionsearch antigen processing and presentationsearch defense response to virussearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of vitamin D biosynthetic processsearch negative regulation of myelinationsearch negative regulation of epithelial cell differentiationsearch defense response to bacteriumsearch negative regulation of interleukin-17 productionsearch cellular response to interleukin-18search negative regulation of cell proliferationsearch response to drugsearch regulation of the force of heart contractionsearch endoplasmic reticulum unfolded protein responsesearch immune responsesearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of tumor necrosis factor productionsearch neutrophil apoptotic processsearch cell cycle arrestsearch positive regulation of synaptic transmission, cholinergicsearch neutrophil chemotaxissearch cellular component movementsearch regulation of insulin secretionsearch positive regulation of cell proliferationsearch positive regulation of chemokine biosynthetic processsearch positive regulation of mesenchymal cell proliferationsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of growthsearch regulation of interferon-gamma-mediated signaling pathwaysearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch response to virussearch cytokine activitysearch interferon-gamma receptor bindingsearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch

Chain InterPro annotation
A, B, C, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch