1hig Summary

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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

The structure was published by Ealick, S.E., Cook, W.J., Vijay-Kumar, S., et al., Nagabhushan, T.L., Trotta, P.P., and Bugg, C.E., in 1991 in a paper entitled "Three-dimensional structure of recombinant human interferon-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of INTERFERON-GAMMA.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
B INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
C INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
D INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (24 - 161) INTERFERON-GAMMA Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D (P01579) Interferons/interleukin-10 (IL-10)search PF00714: Interferon gammasearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D (P01579) extracellular regionsearch extracellular spacesearch external side of plasma membranesearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of osteoclast differentiationsearch positive regulation of membrane protein ectodomain proteolysissearch cell surface receptor signaling pathwaysearch apoptotic processsearch negative regulation of growth of symbiont in hostsearch positive regulation of tumor necrosis factor productionsearch negative regulation of cell proliferationsearch positive regulation of mesenchymal cell proliferationsearch extrinsic apoptotic signaling pathwaysearch interferon-gamma-mediated signaling pathwaysearch defense response to virussearch cellular response to lipopolysaccharidesearch positive regulation of MHC class II biosynthetic processsearch positive regulation of interleukin-6 biosynthetic processsearch defense response to protozoansearch regulation of immune responsesearch negative regulation of smooth muscle cell proliferationsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch adaptive immune responsesearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of transcription, DNA-templatedsearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of interleukin-1 beta secretionsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of interleukin-12 biosynthetic processsearch humoral immune responsesearch negative regulation of epithelial cell differentiationsearch response to drugsearch antigen processing and presentationsearch cellular response to interleukin-18search positive regulation of neuron differentiationsearch regulation of transcription, DNA-templatedsearch negative regulation of interleukin-17 productionsearch positive regulation of vitamin D biosynthetic processsearch inflammatory cell apoptotic processsearch regulation of growthsearch positive regulation of chemokine biosynthetic processsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of interleukin-12 productionsearch regulation of the force of heart contractionsearch positive regulation of cell proliferationsearch neutrophil apoptotic processsearch cell cycle arrestsearch positive regulation of synaptic transmission, cholinergicsearch regulation of insulin secretionsearch negative regulation of myelinationsearch positive regulation of smooth muscle cell apoptotic processsearch regulation of interferon-gamma-mediated signaling pathwaysearch response to virussearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch endoplasmic reticulum unfolded protein responsesearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of T cell proliferationsearch cellular component movementsearch protein import into nucleus, translocationsearch negative regulation of transcription from RNA polymerase II promotersearch cytokine-mediated signaling pathwaysearch positive regulation of interleukin-23 productionsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of cell adhesionsearch positive regulation of killing of cells of other organismsearch defense response to bacteriumsearch neutrophil chemotaxissearch immune responsesearch cytokine activitysearch interferon-gamma receptor bindingsearch

Chain InterPro annotation
A, B, C, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch