1hig Summary

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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

The structure was published by Ealick, S.E., Cook, W.J., Vijay-Kumar, S., et al., Nagabhushan, T.L., Trotta, P.P., and Bugg, C.E., in 1991 in a paper entitled "Three-dimensional structure of recombinant human interferon-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.5 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of INTERFERON-GAMMA.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
B INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
C INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%
D INTERFERON-GAMMA P01579 (24-161) (IFNG_HUMAN)search Homo sapienssearch 90% 138 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (24 - 161) INTERFERON-GAMMA Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D (P01579) Interferons/interleukin-10 (IL-10)search PF00714: Interferon gammasearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P01579) interferon-gamma receptor bindingsearch cytokine activitysearch extracellular regionsearch external side of plasma membranesearch extracellular spacesearch sensory perception of mechanical stimulussearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of osteoclast differentiationsearch positive regulation of membrane protein ectodomain proteolysissearch cell surface receptor signaling pathwaysearch positive regulation of cell adhesionsearch negative regulation of myelinationsearch interferon-gamma-mediated signaling pathwaysearch negative regulation of growth of symbiont in hostsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch antigen processing and presentationsearch apoptotic processsearch extrinsic apoptotic signaling pathwaysearch positive regulation of mesenchymal cell proliferationsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of MHC class II biosynthetic processsearch positive regulation of chemokine biosynthetic processsearch negative regulation of cell proliferationsearch defense response to bacteriumsearch positive regulation of interleukin-12 productionsearch regulation of the force of heart contractionsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch negative regulation of smooth muscle cell proliferationsearch neutrophil apoptotic processsearch positive regulation of vitamin D biosynthetic processsearch defense response to virussearch positive regulation of T cell proliferationsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of synaptic transmission, cholinergicsearch adaptive immune responsesearch humoral immune responsesearch endoplasmic reticulum unfolded protein responsesearch negative regulation of growth of symbiont involved in interaction with hostsearch negative regulation of interleukin-17 productionsearch negative regulation of epithelial cell differentiationsearch positive regulation of interleukin-6 biosynthetic processsearch defense response to protozoansearch positive regulation of epithelial cell migrationsearch positive regulation of isotype switching to IgG isotypessearch regulation of transcription, DNA-templatedsearch positive regulation of interleukin-12 biosynthetic processsearch movement of cell or subcellular componentsearch response to drugsearch positive regulation of cell proliferationsearch positive regulation of neuron differentiationsearch cell cycle arrestsearch positive regulation of transcription, DNA-templatedsearch cellular response to interleukin-18search negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of tumor necrosis factor productionsearch regulation of immune responsesearch regulation of insulin secretionsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of smooth muscle cell apoptotic processsearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to lipopolysaccharidesearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch regulation of neuronal action potentialsearch response to virussearch protein import into nucleus, translocationsearch positive regulation of interleukin-1 beta secretionsearch regulation of hepatocyte proliferationsearch positive regulation of killing of cells of other organismsearch cytokine-mediated signaling pathwaysearch inflammatory cell apoptotic processsearch neutrophil chemotaxissearch positive regulation of interleukin-23 productionsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch regulation of growthsearch immune responsesearch

Chain InterPro annotation
A, B, C, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch