› 1hhz

X-ray diffraction
0.99Å resolution

Deglucobalhimycin in complex with cell wall pentapeptide

Released:
DOI: 10.2210/pdb1hhz/pdb
PDB entry 1hhz coloured by chain, front view.
PDB entry 1hhz coloured by chain, side view.
PDB entry 1hhz coloured by chain, top view.
Source organisms:
Primary publication:
Structures of glycopeptide antibiotics with peptides that model bacterial cell-wall precursors.
Lehmann C, Bunkóczi G, Vértesy L, Sheldrick GM
J Mol Biol 318 723-32 (2002)
PMID: 12054818

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162219 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DEGLUCOBALHIMYCIN Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 7 amino acids
Theoretical weight: 1.15 KDa
Source organism: Amycolatopsis sp.
Expression system: Not provided
CELL WALL PEPTIDE Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 5 amino acids
Theoretical weight: 490 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand DVC 3 x DVC
Ligand PGR 4 x PGR
4 modified residues:
Ligand GHP 6 x GHP
Ligand OMY 3 x OMY
Ligand DAL 9 x DAL
Ligand FGA 3 x FGA

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P3221
Unit cell:
a: 48.29Å b: 48.29Å c: 39.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.108 not available 0.14
Expression system: Not provided

Quick links

Citations

1 review citation

Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics.
Liskamp et al. (2011)
9 other articles

1 mention without citation

Vancomycin forms ligand-mediated supramolecular complexes.
Loll et al. (2009)