1hgc Summary

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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN

The structure was published by Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., and Dodson, G., in 1992 in a paper entitled "High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (OXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (OXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (OXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (OXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch heme bindingsearch oxygen bindingsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch oxygen transportsearch transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of cell deathsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch extracellular regionsearch membranesearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch
B, D (P68871) oxygen transporter activitysearch protein bindingsearch hemoglobin bindingsearch metal ion bindingsearch oxygen bindingsearch peroxidase activitysearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch bicarbonate transportsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch oxygen transportsearch renal absorptionsearch response to hydrogen peroxidesearch oxidation-reduction processsearch positive regulation of cell deathsearch blood coagulationsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch regulation of blood pressuresearch small molecule metabolic processsearch transportsearch regulation of blood vessel sizesearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch cytosolsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch