1hgc Summary

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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN

The structure was published by Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., and Dodson, G., in 1992 in a paper entitled "High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (OXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (OXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (OXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (OXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch extracellular regionsearch membranesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch cytosolsearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch
B, D (P68871) heme bindingsearch iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch transportsearch positive regulation of nitric oxide biosynthetic processsearch oxygen transportsearch renal absorptionsearch response to hydrogen peroxidesearch bicarbonate transportsearch nitric oxide transportsearch blood coagulationsearch protein heterooligomerizationsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch platelet aggregationsearch small molecule metabolic processsearch regulation of blood pressuresearch oxidation-reduction processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch