1hgb Summary

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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN

The structure was published by Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., and Dodson, G., in 1992 in a paper entitled "High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) and HEMOGLOBIN (AQUO MET) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (AQUO MET) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (AQUO MET) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (AQUO MET) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch membranesearch cytosolsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch bicarbonate transportsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch positive regulation of cell deathsearch oxygen transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch
B, D (P68871) blood microparticlesearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch renal absorptionsearch oxidation-reduction processsearch transportsearch positive regulation of cell deathsearch blood coagulationsearch bicarbonate transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch regulation of blood pressuresearch nitric oxide transportsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch small molecule metabolic processsearch heme bindingsearch hemoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch metal ion bindingsearch iron ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch