1hgb Summary

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HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN

The structure was published by Liddington, R., Derewenda, Z., Dodson, E., Hubbard, R., and Dodson, G., in 1992 in a paper entitled "High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1991.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) and HEMOGLOBIN (AQUO MET) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (AQUO MET) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (AQUO MET) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (AQUO MET) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (AQUO MET) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch membranesearch blood microparticlesearch
B, D (P68871) oxygen transportsearch regulation of blood vessel sizesearch blood coagulationsearch regulation of blood pressuresearch protein heterooligomerizationsearch nitric oxide transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch transportsearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch iron ion bindingsearch oxygen bindingsearch peroxidase activitysearch protein bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch heme bindingsearch extracellular regionsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch