1hfe Summary

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1.6 A RESOLUTION STRUCTURE OF THE FE-ONLY HYDROGENASE FROM DESULFOVIBRIO DESULFURICANS

The structure was published by Nicolet, Y., Piras, C., Legrand, P., Hatchikian, C.E., and Fontecilla-Camps, J.C., in 1999 in a paper entitled "Desulfovibrio desulfuricans iron hydrogenase: the structure shows unusual coordination to an active site Fe binuclear center." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (SMALLER SUBUNIT)) and PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (LARGER SUBUNIT)).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
S PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (SMALLER SUBUNIT)) P07603 (1-123) (PHFS_DESVH)search Desulfovibrio vulgaris str. Hildenboroughsearch 99% 123 71%
T PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (SMALLER SUBUNIT)) P07603 (1-123) (PHFS_DESVH)search Desulfovibrio vulgaris str. Hildenboroughsearch 99% 123 71%
L PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (LARGER SUBUNIT)) P07598 (1-421) (PHFL_DESVH)search Desulfovibrio vulgaris str. Hildenboroughsearch 100% 421 94%
M PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (LARGER SUBUNIT)) P07598 (1-421) (PHFL_DESVH)search Desulfovibrio vulgaris str. Hildenboroughsearch 100% 421 94%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P07603 (1 - 123) PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (SMALLER SUBUNIT)) Desulfovibrio vulgaris str. Hildenborough
P07598 (1 - 421) PROTEIN (FE-ONLY HYDROGENASE (E.C.1.18.99.1) (LARGER SUBUNIT)) Desulfovibrio vulgaris str. Hildenborough

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
S, T (P07603) Fe-only hydrogenase smaller subunitsearch G Protein Gi Gamma 2search PF02256: Iron hydrogenase small subunitsearch
L, M (P07598) Fe-only hydrogenasesearch, Ferredoxin domains from multidomain proteinssearch Rossmann foldsearch, Alpha-Beta Plaitssearch, Fe-only Hydrogenase (Larger Subunit); Chain L, domain 3search PF00037: 4Fe-4S binding domainsearch, PF02906: Iron only hydrogenase large subunit, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
S, T (P07603) electron carrier activitysearch iron-sulfur cluster bindingsearch ferredoxin hydrogenase activitysearch iron ion bindingsearch periplasmic spacesearch
L, M (P07598) iron ion bindingsearch iron-sulfur cluster bindingsearch ferredoxin hydrogenase activitysearch 4 iron, 4 sulfur cluster bindingsearch metal ion bindingsearch oxidoreductase activitysearch oxidation-reduction processsearch periplasmic spacesearch

Chain InterPro annotation
S, T Iron hydrogenase, small subunit-likesearch Twin-arginine translocation pathway, signal sequencesearch Iron hydrogenase, small subunitsearch Twin-arginine translocation pathway, signal sequence, bacterial/archaealsearch
L, M 4Fe-4S binding domainsearch Iron hydrogenase, large subunit, C-terminalsearch Iron hydrogenasesearch Iron hydrogenase, subsetsearch 4Fe-4S ferredoxin-type, iron-sulphur binding domainsearch 4Fe-4S ferredoxin, iron-sulphur binding, conserved sitesearch