1hec Summary

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STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II

The structure was published by Nair, S.K. and Christianson, D.W., in 1993 in a paper entitled "Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) positive regulation of synaptic transmission, GABAergicsearch morphogenesis of an epitheliumsearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch kidney developmentsearch response to pHsearch bicarbonate transportsearch one-carbon metabolic processsearch response to organic substancesearch positive regulation of cellular pH reductionsearch small molecule metabolic processsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch secretionsearch response to steroid hormonesearch regulation of anion transportsearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch response to estrogensearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch cytosolsearch axonsearch cytoplasmsearch plasma membranesearch extracellular spacesearch membranesearch myelin sheathsearch apical part of cellsearch extracellular vesicular exosomesearch basolateral plasma membranesearch microvillussearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch