1heb Summary

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STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II

The structure was published by Nair, S.K. and Christianson, D.W., in 1993 in a paper entitled "Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch cytoplasmsearch apical part of cellsearch basolateral plasma membranesearch membranesearch cytosolsearch myelin sheathsearch plasma membranesearch axonsearch extracellular vesicular exosomesearch microvillussearch extracellular spacesearch morphogenesis of an epitheliumsearch bicarbonate transportsearch odontogenesis of dentin-containing toothsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch small molecule metabolic processsearch response to organic substancesearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch secretionsearch regulation of anion transportsearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch response to estrogensearch kidney developmentsearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch response to zinc ionsearch positive regulation of bone resorptionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch