1hdb Summary

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ANALYSIS OF THE CRYSTAL STRUCTURE, MOLECULAR MODELING AND INFRARED SPECTROSCOPY OF THE DISTAL BETA-HEME POCKET VALINE67(E11)-THREONINE MUTATION OF HEMOGLOBIN

The structure was published by Pechik, I., Ji, X., Fidelis, K., et al., Brinigar, W.S., Fronticelli, C., and Gilliland, G.L., in 1996 in a paper entitled "Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) BETA-V67T.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) BETA-V67T P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) BETA-V67T P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) BETA-V67T P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) BETA-V67T P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) BETA-V67T Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) BETA-V67T Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch bicarbonate transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch protein heterooligomerizationsearch transportsearch hemoglobin complexsearch extracellular regionsearch membranesearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch cytosolsearch blood microparticlesearch
B, D (P68871) oxygen bindingsearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch protein bindingsearch peroxidase activitysearch hemoglobin bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transportsearch renal absorptionsearch regulation of blood vessel sizesearch oxidation-reduction processsearch protein heterooligomerizationsearch bicarbonate transportsearch regulation of blood pressuresearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch positive regulation of cell deathsearch nitric oxide transportsearch blood coagulationsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch transportsearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch