1hd4 Summary

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SOLUTION STRUCTURE OF THE A-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN [MODELED WITH DIANTENNARY GLYCAN AT ASN78]

The structure was published by Erbel, P.J.A., Karimi-Nejad, Y., Van Kuik, J.A., Boelens, R., Kamerling, J.P., and Vliegenthart, J.F.G., in 2000 in a paper entitled "Effects of the N-Linked Glycans on the 3D Structure of the Free A-Subunit of Human Chorionic Gonadotropin" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CHORIONIC GONADOTROPIN. This molecule has the UniProt identifier P01215 (GLHA_HUMAN)search. The sample contained 92 residues which is 100% of the natural sequence. Out of 92 residues 92 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CHORIONIC GONADOTROPIN P01215 (25-116) (GLHA_HUMAN)search Homo sapienssearch 100% 92 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01215 (25 - 116) CHORIONIC GONADOTROPIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P01215) Gonadodropin/Follitropinsearch Cystine-knot cytokinessearch PF00236: Glycoprotein hormonesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P01215) extracellular regionsearch protein bindingsearch hormone activitysearch thyroid gland developmentsearch positive regulation of cell migrationsearch positive regulation of transcription from RNA polymerase II promotersearch developmental growthsearch signal transductionsearch peptide hormone processingsearch cellular protein metabolic processsearch luteinizing hormone secretionsearch negative regulation of organ growthsearch cell-cell signalingsearch cellular response to hormone stimulussearch thyroid hormone generationsearch gonad developmentsearch positive regulation of cell proliferationsearch follicle-stimulating hormone secretionsearch

Chain InterPro annotation
A Glycoprotein hormone alpha chainsearch Cystine-knot cytokinesearch