1hcq Summary

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THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS

The structure was published by Schwabe, J.W., Chapman, L., Finch, J.T., and Rhodes, D., in 1993 in a paper entitled "The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP*CP*CP*T P*G)-3'), DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP*CP*CP*T P*G)-3'), and PROTEIN (ESTROGEN RECEPTOR).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (ESTROGEN RECEPTOR) P03372 (180-262) (ESR1_HUMAN)search Homo sapienssearch < 90% 84 88%
B PROTEIN (ESTROGEN RECEPTOR) P03372 (180-262) (ESR1_HUMAN)search Homo sapienssearch < 90% 84 88%
E PROTEIN (ESTROGEN RECEPTOR) P03372 (180-262) (ESR1_HUMAN)search Homo sapienssearch < 90% 84 88%
F PROTEIN (ESTROGEN RECEPTOR) P03372 (180-262) (ESR1_HUMAN)search Homo sapienssearch < 90% 84 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (180 - 262) PROTEIN (ESTROGEN RECEPTOR) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, E, F Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search, Oestrogen receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, E, F (P03372) sequence-specific DNA bindingsearch zinc ion bindingsearch DNA bindingsearch calcitriol receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B, E, F Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch