1hcp Summary

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DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL

The structure was published by Schwabe, J.W., Chapman, L., Finch, J.T., Rhodes, D., and Neuhaus, D., in 1993 in a paper entitled "DNA recognition by the oestrogen receptor: from solution to the crystal." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1993.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of HUMAN/CHICKEN ESTROGEN RECEPTOR. This molecule has the UniProt identifier P03372 (ESR1_HUMAN)search. The sample contained 76 residues which is < 90% of the natural sequence. Out of 76 residues 75 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HUMAN/CHICKEN ESTROGEN RECEPTOR P03372 (180-254) (ESR1_HUMAN)search Homo sapienssearch < 90% 76 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03372 (180 - 254) HUMAN/CHICKEN ESTROGEN RECEPTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search, Oestrogen receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P03372) sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch zinc ion bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch