1hco Summary

pdbe.org/1hco
spacer

THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION

The structure was published by Baldwin, J.M., in 1980 in a paper entitled "The structure of human carbonmonoxy haemoglobin at 2.7 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 1979.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P69905) oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch protein heterooligomerizationsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch hemoglobin complexsearch extracellular regionsearch membranesearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch blood microparticlesearch
B (P68871) hydrogen peroxide catabolic processsearch oxygen transportsearch platelet aggregationsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch regulation of blood vessel sizesearch nitric oxide transportsearch regulation of blood pressuresearch oxidation-reduction processsearch blood coagulationsearch small molecule metabolic processsearch response to hydrogen peroxidesearch transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch protein bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch blood microparticlesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch