1hcl Summary



The structure was published by Schulze-Gahmen, U., De Bondt, H.L., and Kim, S.H., in 1996 in a paper entitled "High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of HUMAN CYCLIN-DEPENDENT KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 294 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HUMAN CYCLIN-DEPENDENT KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) HUMAN CYCLIN-DEPENDENT KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch ATP bindingsearch histone kinase activitysearch metal ion bindingsearch kinase activitysearch transferase activitysearch protein phosphorylationsearch mitotic nuclear divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA replicationsearch centrosome duplicationsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch histone phosphorylationsearch positive regulation of DNA-dependent DNA replication initiationsearch G2/M transition of mitotic cell cyclesearch meiotic nuclear divisionsearch potassium ion transportsearch DNA repairsearch cellular response to DNA damage stimulussearch phosphorylationsearch regulation of gene silencingsearch cellular response to nitric oxidesearch mitotic G1 DNA damage checkpointsearch cell divisionsearch positive regulation of cell proliferationsearch mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell cyclesearch positive regulation of transcription, DNA-templatedsearch blood coagulationsearch nucleoplasmsearch condensed chromosomesearch endosomesearch cytoplasmsearch centrosomesearch transcription factor complexsearch cytosolsearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch cytoskeletonsearch Y chromosomesearch nucleussearch microtubule organizing centersearch Cajal bodysearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch