1hck Summary

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HUMAN CYCLIN-DEPENDENT KINASE 2

The structure was published by Schulze-Gahmen, U., De Bondt, H.L., and Kim, S.H., in 1996 in a paper entitled "High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of HUMAN CYCLIN-DEPENDENT KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 294 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HUMAN CYCLIN-DEPENDENT KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) HUMAN CYCLIN-DEPENDENT KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein serine/threonine kinase activitysearch protein bindingsearch kinase activitysearch transferase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch histone kinase activitysearch cyclin bindingsearch metal ion bindingsearch protein phosphorylationsearch cell cyclesearch phosphorylationsearch centrosome duplicationsearch regulation of gene silencingsearch G2/M transition of mitotic cell cyclesearch mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch meiotic nuclear divisionsearch cellular response to DNA damage stimulussearch mitotic nuclear divisionsearch DNA replicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch potassium ion transportsearch cell divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch blood coagulationsearch histone phosphorylationsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch positive regulation of cell proliferationsearch DNA repairsearch positive regulation of transcription, DNA-templatedsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to nitric oxidesearch cytosolsearch nucleoplasmsearch centrosomesearch endosomesearch chromosome, telomeric regionsearch Cajal bodysearch microtubule organizing centersearch nucleussearch cytoplasmsearch cytoskeletonsearch transcription factor complexsearch Y chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch condensed chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch