1hcb Summary

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ENZYME-SUBSTRATE INTERACTIONS: STRUCTURE OF HUMAN CARBONIC ANHYDRASE I COMPLEXED WITH BICARBONATE

The structure was published by Kumar, V. and Kannan, K.K., in 1994 in a paper entitled "Enzyme-substrate interactions. Structure of human carbonic anhydrase I complexed with bicarbonate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 1994.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE I. This molecule has the UniProt identifier P00915 (CAH1_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE I P00915 (2-261) (CAH1_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00915 (2 - 261) CARBONIC ANHYDRASE I Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00915) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00915) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch bicarbonate transportsearch one-carbon metabolic processsearch small molecule metabolic processsearch extracellular vesicular exosomesearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA1search Carbonic anhydrase, alpha-classsearch