1hbs Summary

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REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION

The structure was published by Padlan, E.A. and Love, W.E., in 1985 in a paper entitled "Refined crystal structure of deoxyhemoglobin S. I. Restrained least-squares refinement at 3.0-A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1982.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN S (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN S (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C, E, G (P69905) hemoglobin complexsearch extracellular regionsearch cytosolsearch cytosolic small ribosomal subunitsearch membranesearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch blood microparticlesearch endocytic vesicle lumensearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch response to hydrogen peroxidesearch transportsearch oxygen transportsearch small molecule metabolic processsearch bicarbonate transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch
B, D, F, H (P68871) hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch bicarbonate transportsearch renal absorptionsearch regulation of blood pressuresearch small molecule metabolic processsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch oxygen transportsearch transportsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch positive regulation of cell deathsearch platelet aggregationsearch oxidation-reduction processsearch blood coagulationsearch response to hydrogen peroxidesearch regulation of blood vessel sizesearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch