1hbs Summary

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REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION

The structure was published by Padlan, E.A. and Love, W.E., in 1985 in a paper entitled "Refined crystal structure of deoxyhemoglobin S. I. Restrained least-squares refinement at 3.0-A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1982.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN S (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H HEMOGLOBIN S (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN S (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN S (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C, E, G (P69905) haptoglobin-hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch cytosolic small ribosomal subunitsearch membranesearch oxidation-reduction processsearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch oxygen transportsearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch protein heterooligomerizationsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch peroxidase activitysearch haptoglobin bindingsearch
B, D, F, H (P68871) extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch nitric oxide transportsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch renal absorptionsearch oxygen transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch blood coagulationsearch platelet aggregationsearch transportsearch regulation of blood vessel sizesearch regulation of blood pressuresearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch iron ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch protein bindingsearch haptoglobin bindingsearch heme bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch