› 1hbb

X-ray diffraction
1.9Å resolution

HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE

Released:
DOI: 10.2210/pdb1hbb/pdb
PDB entry 1hbb coloured by chain, front view.
PDB entry 1hbb coloured by chain, side view.
PDB entry 1hbb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site.
Kavanaugh JS, Rogers PH, Case DA, Arnone A
Biochemistry 31 4111-21 (1992)
PMID: 1567857

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

1 bound ligand:
Ligand HEM 4 x HEM
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 97Å b: 99.3Å c: 66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 not available not available
Expression system: Not provided

Quick links

Citations

2 review citations

Hemoglobin: Structure, Function and Allostery.
Ahmed et al. (2020)
1 more

7 mentions without citation

Estimating hydration changes upon biomolecular reactions from osmotic stress, high pressure, and preferential hydration experiments.
Shimizu S. (2004)
6 more