1hbb Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE

The structure was published by Kavanaugh, J.S., Rogers, P.H., Case, D.A., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN A (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch heme bindingsearch peroxidase activitysearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch membranesearch cytosolsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch oxygen transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch transportsearch bicarbonate transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch
B, D (P68871) oxygen bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch oxygen transportsearch receptor-mediated endocytosissearch blood coagulationsearch response to hydrogen peroxidesearch transportsearch platelet aggregationsearch regulation of blood vessel sizesearch bicarbonate transportsearch regulation of blood pressuresearch renal absorptionsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch