1hbb Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE

The structure was published by Kavanaugh, J.S., Rogers, P.H., Case, D.A., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN A (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch small molecule metabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch bicarbonate transportsearch transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein bindingsearch haptoglobin bindingsearch iron ion bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch membranesearch blood microparticlesearch cytosolsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch
B, D (P68871) oxygen transportsearch regulation of blood pressuresearch blood coagulationsearch response to hydrogen peroxidesearch renal absorptionsearch bicarbonate transportsearch small molecule metabolic processsearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch protein heterooligomerizationsearch nitric oxide transportsearch transportsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch hemoglobin bindingsearch peroxidase activitysearch heme bindingsearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch