1hba Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE

The structure was published by Kavanaugh, J.S., Rogers, P.H., Case, D.A., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch cytosolic small ribosomal subunitsearch membranesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen transportsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch bicarbonate transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch
B, D (P68871) hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch peroxidase activitysearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch platelet aggregationsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch regulation of blood vessel sizesearch transportsearch renal absorptionsearch nitric oxide transportsearch blood coagulationsearch regulation of blood pressuresearch positive regulation of cell deathsearch oxidation-reduction processsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch