1hba Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE

The structure was published by Kavanaugh, J.S., Rogers, P.H., Case, D.A., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch cytosolic small ribosomal subunitsearch membranesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch heme bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch oxygen transportsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch
B, D (P68871) extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch transportsearch small molecule metabolic processsearch oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch platelet aggregationsearch blood coagulationsearch renal absorptionsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch nitric oxide transportsearch receptor-mediated endocytosissearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch