1hba Summary

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HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE

The structure was published by Kavanaugh, J.S., Rogers, P.H., Case, D.A., and Arnone, A., in 1992 in a paper entitled "High-resolution X-ray study of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ROTHSCHILD (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN ROTHSCHILD (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) protein heterooligomerizationsearch bicarbonate transportsearch oxidation-reduction processsearch oxygen transportsearch transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch small molecule metabolic processsearch response to hydrogen peroxidesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch extracellular regionsearch hemoglobin complexsearch cytosolsearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch
B, D (P68871) oxygen transportsearch blood coagulationsearch renal absorptionsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch regulation of blood vessel sizesearch platelet aggregationsearch small molecule metabolic processsearch bicarbonate transportsearch transportsearch regulation of blood pressuresearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch positive regulation of cell deathsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch cytosolsearch oxygen bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch