1hac Summary

pdbe.org/1hac
spacer

CROSSLINKED HAEMOGLOBIN

The structure was published by Schumacher, M.A., Zheleznova, E.E., Poundstone, K.S., Kluger, R., Jones, R.T., and Brennan, R.G., in 1997 in a paper entitled "Allosteric intermediates indicate R2 is the liganded hemoglobin end state." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN A P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN A P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) protein bindingsearch oxygen transporter activitysearch heme bindingsearch peroxidase activitysearch oxygen bindingsearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch membranesearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch cytosolic small ribosomal subunitsearch cytosolsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch small molecule metabolic processsearch response to hydrogen peroxidesearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch
B, D (P68871) iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch heme bindingsearch metal ion bindingsearch peroxidase activitysearch cytosolsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch oxygen transportsearch platelet aggregationsearch hydrogen peroxide catabolic processsearch transportsearch regulation of blood vessel sizesearch regulation of blood pressuresearch positive regulation of cell deathsearch bicarbonate transportsearch small molecule metabolic processsearch blood coagulationsearch nitric oxide transportsearch protein heterooligomerizationsearch renal absorptionsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch