1h9o Summary

pdbe.org/1h9o
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PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A

The structure was published by Pauptit, R.A., Dennis, C.A., Derbyshire, D.J., et al., Weston, S.A., Rowsell, S., and Murshudov, G.N., in 2001 in a paper entitled "NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.79 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PHOSPHATIDYLINOSITOL 3-KINASE and BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL 3-KINASE P27986 (617-724) (P85A_HUMAN)search Homo sapienssearch < 90% 112 97%
B BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR P09619 (751-755) (PGFRB_HUMAN)search Homo sapienssearch < 90% 5 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P27986 (617 - 724) PHOSPHATIDYLINOSITOL 3-KINASE Homo sapiens
P09619 (751 - 755) BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR HOMO SAPIENS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
B Protein tyrosine kinasesearch

Chain ID Cellular component (GO) Molecular function (GO)
A (P27986) phosphatidylinositol 3-kinase complexsearch phosphatidylinositol 3-kinase regulator activitysearch

Chain InterPro annotation
A SH2 domainsearch PI3 kinase, P85 regulatory subunitsearch
B