1h9n Summary



The structure was published by Lesburg, C.A., Huang, C., Christianson, D.W., and Fierke, C.A., in 1997 in a paper entitled "Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) cytosolsearch cytoplasmsearch axonsearch plasma membranesearch apical part of cellsearch myelin sheathsearch extracellular vesicular exosomesearch microvillussearch membranesearch basolateral plasma membranesearch extracellular spacesearch lyase activitysearch metal ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch small molecule metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch bicarbonate transportsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch positive regulation of cellular pH reductionsearch response to organic substancesearch response to steroid hormonesearch response to estrogensearch secretionsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch kidney developmentsearch regulation of anion transportsearch response to pHsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch regulation of chloride transportsearch positive regulation of osteoclast differentiationsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch