1h8b Summary

pdbe.org/1h8b
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EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN

The structure was published by Atkinson, R.A., Joseph, C., Kelly, G., et al., Frenkiel, T.A., Nietlispach, D., and Pastore, A., in 2001 in a paper entitled "Ca2+-Independent Binding of an EF-Hand Domain to a Novel Motif in the Alpha-Actinin-Titin Complex" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ALPHA-ACTININ 2, SKELETAL MUSCLE ISOFORM and TITIN.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ALPHA-ACTININ 2, SKELETAL MUSCLE ISOFORM P35609 (822-894) (ACTN2_HUMAN)search Homo sapienssearch < 90% 75 97%
B TITIN O97791 (648-698) (O97791_RABIT)search Oryctolagus cuniculussearch < 90% 53 43%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P35609 (822 - 894) ALPHA-ACTININ 2, SKELETAL MUSCLE ISOFORM Homo sapiens
O97791 (648 - 698) TITIN Oryctolagus cuniculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A EF-hand modules in multidomain proteinssearch EF-handsearch Ca2+ insensitive EF handsearch
B Single helix binsearch Titin Zsearch

Chain ID Molecular function (GO)
A (P35609) calcium ion bindingsearch

Chain InterPro annotation
A EF-hand domain pairsearch EF-hand, Ca insensitivesearch
B Titin Zsearch