1h89 Summary

pdbe.org/1h89
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CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX2

The structure was published by Tahirov, T.H., Sato, K., Ichikawa-Iwata, E., et al., Yamamoto, M., Ishii, S., and Ogata, K., in 2002 in a paper entitled "Mechanism of C-Myb-C/Ebpbeta Cooperation from Separated Sites on a Promoter" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CAAT/ENHANCER BINDING PROTEIN BETA P17676 (273-336) (CEBPB_HUMAN)search Homo sapienssearch < 90% 64 100%
B CAAT/ENHANCER BINDING PROTEIN BETA P17676 (273-336) (CEBPB_HUMAN)search Homo sapienssearch < 90% 64 100%
C MYB PROTO-ONCOGENE PROTEIN P06876 (37-193) (MYB_MOUSE)search Mus musculussearch < 90% 159 72%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P17676 (273 - 336) CAAT/ENHANCER BINDING PROTEIN BETA Homo sapiens
P06876 (37 - 193) MYB PROTO-ONCOGENE PROTEIN Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Basic region leucine zippersearch
C Myb/SANT domainsearch Homeodomain-likesearch Myb-like DNA-binding domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P17676) regulation of transcription, DNA-templatedsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch
C (P06876) chromatin bindingsearch DNA bindingsearch

Chain InterPro annotation
A, B Basic-leucine zipper domainsearch
C SANT/Myb domainsearch Homeodomain-likesearch Myb domainsearch