1h89 › Citations

Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.

Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K
Cell 108 57-70 (2002)
Related entries: 1h88, 1h8a, 1hjb, 1hjc, 1io4

Cited: 111 times
EuropePMC logo PMID: 11792321

Abstract

c-Myb, but not avian myeloblastosis virus (AMV) v-Myb, cooperates with C/EBP beta to regulate transcription of myeloid-specific genes. To assess the structural basis for that difference, we determined the crystal structures of complexes comprised of the c-Myb or AMV v-Myb DNA-binding domain (DBD), the C/EBP beta DBD, and a promoter DNA fragment. Within the c-Myb complex, a DNA-bound C/EBP beta interacts with R2 of c-Myb bound to a different DNA fragment; point mutations in v-Myb R2 eliminate such interaction within the v-Myb complex. GST pull-down assays, luciferase trans-activation assays, and atomic force microscopy confirmed that the interaction of c-Myb and C/EBP beta observed in crystal mimics their long range interaction on the promoter, which is accompanied by intervening DNA looping.

Reviews - 1h89 mentioned but not cited (1)

  1. The importance of being flexible: the case of basic region leucine zipper transcriptional regulators. Miller M. Curr Protein Pept Sci 10 244-269 (2009)

Articles - 1h89 mentioned but not cited (10)

  1. Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. Wolski SC, Kuper J, Hänzelmann P, Truglio JJ, Croteau DL, Van Houten B, Kisker C. PLoS Biol 6 e149 (2008)
  2. The Protein-DNA Interface database. Norambuena T, Melo F. BMC Bioinformatics 11 262 (2010)
  3. Crystal structure of the chromodomain helicase DNA-binding protein 1 (Chd1) DNA-binding domain in complex with DNA. Sharma A, Jenkins KR, Héroux A, Bowman GD. J Biol Chem 286 42099-42104 (2011)
  4. Relating destabilizing regions to known functional sites in proteins. Dessailly BH, Lensink MF, Wodak SJ. BMC Bioinformatics 8 141 (2007)
  5. Local conformational changes in the DNA interfaces of proteins. Sunami T, Kono H. PLoS One 8 e56080 (2013)
  6. A combined computational and experimental approach reveals the structure of a C/EBPβ-Spi1 interaction required for IL1B gene transcription. Pulugulla SH, Pulugulla SH, Workman R, Rutter NW, Yang Z, Adamik J, Lupish B, Macar DA, El Abdouni S, Esposito EX, Galson DL, Camacho CJ, Madura JD, Auron PE. J Biol Chem 293 19942-19956 (2018)
  7. DNA-binding residues and binding mode prediction with binding-mechanism concerned models. Huang YF, Huang CC, Liu YC, Oyang YJ, Huang CK. BMC Genomics 10 Suppl 3 S23 (2009)
  8. Template-based structure prediction and classification of transcription factors in Arabidopsis thaliana. Lu T, Yang Y, Yao B, Liu S, Zhou Y, Zhang C. Protein Sci 21 828-838 (2012)
  9. Domain-Based Protein Docking with Extremely Large Conformational Changes. Christoffer C, Kihara D. J Mol Biol 434 167820 (2022)
  10. C/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling. Luo Y, Ge P, Wen H, Zhang Y, Liu J, Dong X, Lan B, Zhang G, Yang Q, Chen H. J Inflamm Res 15 5247-5263 (2022)


Reviews citing this publication (11)

  1. CCAAT/enhancer-binding proteins: structure, function and regulation. Ramji DP, Foka P. Biochem J 365 561-575 (2002)
  2. The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation. Tsukada J, Yoshida Y, Kominato Y, Auron PE. Cytokine 54 6-19 (2011)
  3. Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar. Ogata K, Sato K, Tahirov TH. Curr Opin Struct Biol 13 40-48 (2003)
  4. C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS. Pulido-Salgado M, Vidal-Taboada JM, Saura J. Prog Neurobiol 132 1-33 (2015)
  5. A gamut of loops: meandering DNA. Semsey S, Virnik K, Adhya S. Trends Biochem Sci 30 334-341 (2005)
  6. A survey of the year 2002 commercial optical biosensor literature. Rich RL, Myszka DG. J Mol Recognit 16 351-382 (2003)
  7. Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains. Weaver TM, Morrison EA, Musselman CA. Molecules 23 E2614 (2018)
  8. Loops in DNA: an overview of experimental and theoretical approaches. Allemand JF, Cocco S, Douarche N, Lia G. Eur Phys J E Soft Matter 19 293-302 (2006)
  9. Sequence first. Ask questions later. Sidow A. Cell 111 13-16 (2002)
  10. Neurons show the path: tip-to-nucleus communication in filamentous fungal development and pathogenesis. Etxebeste O, Espeso EA. FEMS Microbiol Rev 40 610-624 (2016)
  11. MOLS sampling and its applications in structural biophysics. Ramya L, Nehru Viji S, Arun Prasad P, Kanagasabai V, Gautham N. Biophys Rev 2 169-179 (2010)

Articles citing this publication (89)

  1. Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Zimmermann IM, Heim MA, Weisshaar B, Uhrig JF. Plant J 40 22-34 (2004)
  2. X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Nair SK, Burley SK. Cell 112 193-205 (2003)
  3. Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H. Mol Cell 23 377-387 (2006)
  4. Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI. Grüne T, Brzeski J, Eberharter A, Clapier CR, Corona DF, Becker PB, Müller CW. Mol Cell 12 449-460 (2003)
  5. MYB98 is required for pollen tube guidance and synergid cell differentiation in Arabidopsis. Kasahara RD, Portereiko MF, Sandaklie-Nikolova L, Rabiger DS, Drews GN. Plant Cell 17 2981-2992 (2005)
  6. Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Hatzis P, Talianidis I. Mol Cell 10 1467-1477 (2002)
  7. Structure and mechanism of the chromatin remodelling factor ISW1a. Yamada K, Frouws TD, Angst B, Fitzgerald DJ, DeLuca C, Schimmele K, Sargent DF, Richmond TJ. Nature 472 448-453 (2011)
  8. Bacterial repression loops require enhanced DNA flexibility. Becker NA, Kahn JD, Maher LJ. J Mol Biol 349 716-730 (2005)
  9. Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. Hacking D, Knight JC, Rockett K, Brown H, Frampton J, Kwiatkowski DP, Hull J, Udalova IA. Genes Immun 5 274-282 (2004)
  10. Recruitment of p300 by C/EBPbeta triggers phosphorylation of p300 and modulates coactivator activity. Schwartz C, Beck K, Mink S, Schmolke M, Budde B, Wenning D, Klempnauer KH. EMBO J 22 882-892 (2003)
  11. Two cysteines in plant R2R3 MYB domains participate in REDOX-dependent DNA binding. Heine GF, Hernandez JM, Grotewold E. J Biol Chem 279 37878-37885 (2004)
  12. Sequence-similar, structure-dissimilar protein pairs in the PDB. Kosloff M, Kolodny R. Proteins 71 891-902 (2008)
  13. Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex. Siggers T, Duyzend MH, Reddy J, Khan S, Bulyk ML. Mol Syst Biol 7 555 (2011)
  14. The crystal structure of the C-terminal fragment of striated-muscle alpha-tropomyosin reveals a key troponin T recognition site. Li Y, Mui S, Brown JH, Strand J, Reshetnikova L, Tobacman LS, Cohen C. Proc Natl Acad Sci U S A 99 7378-7383 (2002)
  15. X-ray structure of the complex of regulatory subunits of human DNA polymerase delta. Baranovskiy AG, Babayeva ND, Liston VG, Rogozin IB, Koonin EV, Pavlov YI, Vassylyev DG, Tahirov TH. Cell Cycle 7 3026-3036 (2008)
  16. Mutations in 3'-long terminal repeat of HERV-W family in chromosome 7 upregulate syncytin-1 expression in urothelial cell carcinoma of the bladder through interacting with c-Myb. Yu H, Liu T, Zhao Z, Chen Y, Zeng J, Liu S, Zhu F. Oncogene 33 3947-3958 (2014)
  17. Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation. Pilotto S, Speranzini V, Tortorici M, Durand D, Fish A, Valente S, Forneris F, Mai A, Sixma TK, Vachette P, Mattevi A. Proc Natl Acad Sci U S A 112 2752-2757 (2015)
  18. Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain. Mo X, Kowenz-Leutz E, Laumonnier Y, Xu H, Leutz A. Genes Dev 19 2447-2457 (2005)
  19. The concerted action of bZip and cMyb transcription factors FlbB and FlbD induces brlA expression and asexual development in Aspergillus nidulans. Garzia A, Etxebeste O, Herrero-García E, Ugalde U, Espeso EA. Mol Microbiol 75 1314-1324 (2010)
  20. Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner. Dahle Ø, Andersen TØ, Nordgård O, Matre V, Del Sal G, Gabrielsen OS. Eur J Biochem 270 1338-1348 (2003)
  21. miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb. Chen Z, Stelekati E, Kurachi M, Yu S, Cai Z, Manne S, Khan O, Yang X, Wherry EJ. Cell Rep 20 2584-2597 (2017)
  22. Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties. Garces RG, Gillon W, Pai EF. Protein Sci 16 176-188 (2007)
  23. Structural basis for DNA recognition and loading into a viral packaging motor. Büttner CR, Chechik M, Ortiz-Lombardía M, Smits C, Ebong IO, Chechik V, Jeschke G, Dykeman E, Benini S, Robinson CV, Alonso JC, Antson AA. Proc Natl Acad Sci U S A 109 811-816 (2012)
  24. Cooperative interaction of C/EBP beta and Tat modulates MCP-1 gene transcription in astrocytes. Abraham S, Sweet T, Sawaya BE, Rappaport J, Khalili K, Amini S. J Neuroimmunol 160 219-227 (2005)
  25. v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter. Chayka O, Kintscher J, Braas D, Klempnauer KH. Mol Cell Biol 25 499-511 (2005)
  26. Path of DNA within the Mu transpososome. Transposase interactions bridging two Mu ends and the enhancer trap five DNA supercoils. Pathania S, Jayaram M, Harshey RM. Cell 109 425-436 (2002)
  27. Solution structure of the SWIRM domain of human histone demethylase LSD1. Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Watanabe S, Tomo Y, Hanada M, Ikari M, Sato M, Terada T, Nagase T, Ohara O, Shirouzu M, Tanaka A, Kigawa T, Yokoyama S. Structure 14 457-468 (2006)
  28. C/EBPbeta activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein/P300. Wang H, Larris B, Peiris TH, Zhang L, Le Lay J, Gao Y, Greenbaum LE. J Biol Chem 282 24679-24688 (2007)
  29. Structural and functional differences of SWIRM domain subtypes. Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S. J Mol Biol 369 222-238 (2007)
  30. Energetics of the protein-DNA-water interaction. Spyrakis F, Cozzini P, Bertoli C, Marabotti A, Kellogg GE, Mozzarelli A. BMC Struct Biol 7 4 (2007)
  31. Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells. Fang F, Rycyzyn MA, Clevenger CV. Endocrinology 150 1597-1606 (2009)
  32. Rtf1-mediated eukaryotic site-specific replication termination. Eydmann T, Sommariva E, Inagawa T, Mian S, Klar AJ, Dalgaard JZ. Genetics 180 27-39 (2008)
  33. CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP). Lee S, Miller M, Shuman JD, Johnson PF. J Biol Chem 285 21399-21410 (2010)
  34. Regulation of Bcl-2 expression by C/EBP in t(14;18) lymphoma cells. Heckman CA, Wheeler MA, Boxer LM. Oncogene 22 7891-7899 (2003)
  35. Structural insights into target DNA recognition by R2R3-MYB transcription factors. Wang B, Luo Q, Li Y, Yin L, Zhou N, Li X, Gan J, Dong A. Nucleic Acids Res 48 460-471 (2020)
  36. A single amino acid change within the R2 domain of the VvMYB5b transcription factor modulates affinity for protein partners and target promoters selectivity. Hichri I, Deluc L, Barrieu F, Bogs J, Mahjoub A, Regad F, Gallois B, Granier T, Trossat-Magnin C, Gomès E, Lauvergeat V. BMC Plant Biol 11 117 (2011)
  37. Characterization of PfMyb1 transcription factor during erythrocytic development of 3D7 and F12 Plasmodium falciparum clones. Boschet C, Gissot M, Briquet S, Hamid Z, Claudel-Renard C, Vaquero C. Mol Biochem Parasitol 138 159-163 (2004)
  38. Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. Hortschansky P, Ando E, Tuppatsch K, Arikawa H, Kobayashi T, Kato M, Haas H, Brakhage AA. J Biol Chem 290 6058-6070 (2015)
  39. Structure of NFAT bound to DNA as a monomer. Stroud JC, Chen L. J Mol Biol 334 1009-1022 (2003)
  40. ZNF202 is inversely regulated with its target genes ABCA1 and apoE during macrophage differentiation and foam cell formation. Langmann T, Schumacher C, Morham SG, Honer C, Heimerl S, Moehle C, Schmitz G. J Lipid Res 44 968-977 (2003)
  41. Identification of Egr1 as the oncostatin M-induced transcription activator that binds to sterol-independent regulatory element of human LDL receptor promoter. Zhang F, Ahlborn TE, Li C, Kraemer FB, Liu J. J Lipid Res 43 1477-1485 (2002)
  42. MYT3, a Myb-like transcription factor, affects fungal development and pathogenicity of Fusarium graminearum. Kim Y, Kim H, Son H, Choi GJ, Kim JC, Lee YW. PLoS One 9 e94359 (2014)
  43. Interactions between the R2R3-MYB transcription factor, AtMYB61, and target DNA binding sites. Prouse MB, Campbell MM. PLoS One 8 e65132 (2013)
  44. A unique right end-enhancer complex precedes synapsis of Mu ends: the enhancer is sequestered within the transpososome throughout transposition. Pathania S, Jayaram M, Harshey RM. EMBO J 22 3725-3736 (2003)
  45. A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Ogata K. J Mol Biol 427 1655-1669 (2015)
  46. Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression. Kasper LH, Fukuyama T, Lerach S, Chang Y, Xu W, Wu S, Boyd KL, Brindle PK. PLoS One 8 e82684 (2013)
  47. Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation. Wei SY, Lou YC, Tsai JY, Ho MR, Chou CC, Rajasekaran M, Hsu HM, Tai JH, Hsiao CD, Chen C. Nucleic Acids Res 40 449-460 (2012)
  48. A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. Ko ER, Ko D, Chen C, Lipsick JS. Mol Cancer 7 77 (2008)
  49. Structure of the SANT domain from the Xenopus chromatin remodeling factor ISWI. Horton JR, Elgar SJ, Khan SI, Zhang X, Wade PA, Cheng X. Proteins 67 1198-1202 (2007)
  50. Effects of the SANT domain of tension-induced/inhibited proteins (TIPs), novel partners of the histone acetyltransferase p300, on p300 activity and TIP-6-induced adipogenesis. Badri KR, Zhou Y, Dhru U, Aramgam S, Schuger L. Mol Cell Biol 28 6358-6372 (2008)
  51. Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb. Wilczek C, Chayka O, Plachetka A, Klempnauer KH. J Biol Chem 284 35314-35324 (2009)
  52. Phosphorylation-dependent down-regulation of c-Myb DNA binding is abrogated by a point mutation in the v-myb oncogene. Andersson KB, Kowenz-Leutz E, Brendeford EM, Tygsett AH, Leutz A, Gabrielsen OS. J Biol Chem 278 3816-3824 (2003)
  53. RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis. Lee SH, Hyeon DY, Yoon SH, Jeong JH, Han SM, Jang JW, Nguyen MP, Chi XZ, An S, Hyun KG, Jung HJ, Song JJ, Bae SC, Kim WH, Hwang D, Lee YM. Cell Death Differ 28 1251-1269 (2021)
  54. Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA. Babayeva ND, Baranovskaya OI, Tahirov TH. PLoS One 7 e33698 (2012)
  55. Allosterism and signal transfer in DNA. Balaceanu A, Pérez A, Dans PD, Orozco M. Nucleic Acids Res 46 7554-7565 (2018)
  56. Identification of Putative UL54 (ICP27) Transcription Regulatory Sequences Binding to Oct-1, v-Myb, Pax-6 and Hairy in Herpes Simplex Viruses. Wang YY, Lyu YN, Xin HY, Cheng JT, Liu XQ, Wang XW, Peng XC, Xiang Y, Xin VW, Lu CB, Ren BX, Liang YF, Ji JF, Ma Z, Cui SZ, Xin HW. J Cancer 10 430-440 (2019)
  57. c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors. Flanagan KC, Alspach E, Pazolli E, Parajuli S, Ren Q, Arthur LL, Tapia R, Stewart SA. Oncotarget 9 21-36 (2018)
  58. Characterization of the proximal enhancer element and transcriptional regulatory factors for murine recombination activating gene-2. Wei XC, Dohkan J, Kishi H, Wu CX, Kondo S, Muraguchi A. Eur J Immunol 35 612-621 (2005)
  59. Trimming of mammalian transcriptional networks using network component analysis. Tran LM, Hyduke DR, Liao JC. BMC Bioinformatics 11 511 (2010)
  60. Annular self-assembly of DNA molecular chains occurring in natural dry process of diluted solutions. Morii N, Kido G, Suzuki H, Morii H. Biopolymers 77 163-172 (2005)
  61. Interaction of Epstein-Barr virus BZLF1 C-terminal tail structure and core zipper is required for DNA replication but not for promoter transactivation. McDonald CM, Petosa C, Farrell PJ. J Virol 83 3397-3401 (2009)
  62. Transactivation mediated by B-Myb is dependent on TAF(II)250. Bartusel T, Klempnauer KH. Oncogene 22 2932-2941 (2003)
  63. c-myb activates CXCL12 transcription in T47D and MCF7 breast cancer cells. Chen L, Xu S, Zeng X, Li J, Yin W, Chen Y, Shao Z, Jin W. Acta Biochim Biophys Sin (Shanghai) 42 1-7 (2010)
  64. Developmental regulators FlbE/D orchestrate the polarity site-to-nucleus dynamics of the fungal bZIP transcription factor FlbB. Otamendi A, Perez-de-Nanclares-Arregi E, Oiartzabal-Arano E, Cortese MS, Espeso EA, Etxebeste O. Cell Mol Life Sci 76 4369-4390 (2019)
  65. Identification of the C/EBPα C-terminal tail residues involved in the protein interaction with GABP and their potency in myeloid differentiation of K562 cells. Shimokawa T, Nunomura S, Fujisawa D, Ra C. Biochim Biophys Acta 1829 1207-1217 (2013)
  66. Multiple elements controlling the expression of wheat high molecular weight glutenin paralogs. Makai S, Éva C, Tamás L, Juhász A. Funct Integr Genomics 15 661-672 (2015)
  67. Ribosomal protein L4 positively regulates activity of a c-myb proto-oncogene product. Egoh A, Nosuke Kanesashi S, Kanei-Ishii C, Nomura T, Ishii S. Genes Cells 15 829-841 (2010)
  68. Hydrophobic clusters in protein structures. Arunachalam J, Gautham N. Proteins 71 2012-2025 (2008)
  69. Identification of a Myb-responsive enhancer of the chicken C/EBPbeta gene. Kintscher J, Yamkamon V, Braas D, Klempnauer KH. Oncogene 23 5807-5814 (2004)
  70. Nonstructural Protein 1 of Variant PEDV Plays a Key Role in Escaping Replication Restriction by Complement C3. Fan B, Peng Q, Song S, Shi D, Zhang X, Guo W, Li Y, Zhou J, Zhu X, Zhao Y, Guo R, He K, Fan H, Ding S, Li B. J Virol 96 e0102422 (2022)
  71. Protein structure prediction using mutually orthogonal Latin squares and a genetic algorithm. Arunachalam J, Kanagasabai V, Gautham N. Biochem Biophys Res Commun 342 424-433 (2006)
  72. Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2. Kenchappa CS, Heidarsson PO, Kragelund BB, Garrett RA, Poulsen FM. Nucleic Acids Res 41 3424-3435 (2013)
  73. Structural basis of transcription regulation by CNC family transcription factor, Nrf2. Sengoku T, Shiina M, Suzuki K, Hamada K, Sato K, Uchiyama A, Kobayashi S, Oguni A, Itaya H, Kasahara K, Moriwaki H, Watanabe C, Honma T, Okada C, Baba S, Ohta T, Motohashi H, Yamamoto M, Ogata K. Nucleic Acids Res 50 12543-12557 (2022)
  74. Architectural arrangement of the small nuclear RNA (snRNA)-activating protein complex 190 subunit (SNAP190) on U1 snRNA gene promoter DNA. Doherty MT, Kang YS, Lee C, Stumph WE. J Biol Chem 287 39369-39379 (2012)
  75. Rationally designed coiled-coil DNA looping peptides control DNA topology. Gowetski DB, Kodis EJ, Kahn JD. Nucleic Acids Res 41 8253-8265 (2013)
  76. A NF-κB-dependent dual promoter-enhancer initiates the lipopolysaccharide-mediated transcriptional activation of the chicken lysozyme in macrophages. Witham J, Ouboussad L, Lefevre PF. PLoS One 8 e59389 (2013)
  77. Crystal structure of RecX: a potent regulatory protein of RecA from Xanthomonas campestris. Yang CY, Chin KH, Yang MT, Wang AH, Chou SH. Proteins 74 530-537 (2009)
  78. Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP. Canales Á, Rösinger M, Sastre J, Felli IC, Jiménez-Barbero J, Giménez-Gallego G, Fernández-Tornero C. PLoS One 12 e0189171 (2017)
  79. Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene. Ivanova O, Braas D, Klempnauer KH. Nucleic Acids Res 35 7237-7247 (2007)
  80. The Myb domain of the largest subunit of SNAPc adopts different architectural configurations on U1 and U6 snRNA gene promoter sequences. Kang YS, Kurano M, Stumph WE. Nucleic Acids Res 42 12440-12454 (2014)
  81. Transcriptional Regulation of Latency-Associated Transcripts (LATs) of Herpes Simplex Viruses. Zhang Y, Xin Q, Zhang JY, Wang YY, Cheng JT, Cai WQ, Han ZW, Zhou Y, Cui SZ, Peng XC, Wang XW, Ma Z, Xiang Y, Su XL, Xin HW. J Cancer 11 3387-3399 (2020)
  82. Overexpression of the c-Myb but not its leukemogenic mutant DNA-binding domain increased adipogenic differentiation in mesenchymal stem cells. Chen Y, Liu J, Xu H, Luo Z, Zhang C. Biochem Biophys Res Commun 407 202-206 (2011)
  83. Folding thermodynamics of c-Myb DNA-binding domain in correlation with its α-helical contents. Inaba S, Fukada H, Oda M. Int J Biol Macromol 82 725-732 (2016)
  84. Functional conformer of c-Myb DNA-binding domain revealed by variable temperature studies. Inaba S, Maeno A, Sakurai K, Narayanan SP, Ikegami T, Akasaka K, Oda M. FEBS J 282 4497-4514 (2015)
  85. Dissecting the transactivation domain (tAD) of the transcription factor c-Myb to assess recent models of tAD function. Naes G, Storesund JO, Udayakumar PD, Ledsaak M, Gabrielsen OS. FEBS Open Bio 10 2329-2342 (2020)
  86. Eafs control erythroid cell fate by regulating c-myb expression through Wnt signaling. Ma X, Liu JX. PLoS One 8 e64576 (2013)
  87. Selective inhibition of c-Myb DNA-binding by RNA polymers. Nordgård O, Andersen TØ, Gabrielsen OS. BMC Biochem 5 15 (2004)
  88. Bi-allelic SNAPC4 variants dysregulate global alternative splicing and lead to neuroregression and progressive spastic paraparesis. Frost FG, Morimoto M, Sharma P, Ruaud L, Belnap N, Calame DG, Uchiyama Y, Matsumoto N, Oud MM, Ferreira EA, Narayanan V, Rangasamy S, Huentelman M, Emrick LT, Sato-Shirai I, Kumada S, Wolf NI, Steinbach PJ, Huang Y, Undiagnosed Diseases Network, Pusey BN, Passemard S, Levy J, Drunat S, Vincent M, Guet A, Agolini E, Novelli A, Digilio MC, Rosenfeld JA, Murphy JL, Lupski JR, Vezina G, Macnamara EF, Adams DR, Acosta MT, Tifft CJ, Gahl WA, Malicdan MCV. Am J Hum Genet 110 663-680 (2023)
  89. DNA-binding function of c-Myb R2R3 around thermal denaturation temperature. Kawasaki M, Oda M. Biophys Physicobiol 18 78-84 (2021)


Related citations provided by authors (3)

  1. Crystals of ternary protein-DNA complexes composed of DNA-binding domains of c-Myb or v-Myb, C/EBPalpha or C/EBPbeta and tom-1A promoter fragment.. Tahirov TH, Sasaki M, Inoue-Bungo T, Fujikawa A, Sato K, Kumasaka T, Yamamoto M, Ogata K Acta Crystallogr D Biol Crystallogr 57 1655-8 (2001)
  2. Crystal Structures of C-Myb DNA-Binding Domain in Free State: An Evidence for Binding of Na+ and Comparison with Solution Structure Runt Domain, Cbfbeta and the C/Ebpbeta bZIP Region. Tahirov TH, Morii H, Uedaira H, Sasaki M, Sarai A, Adachi S, Park SY, Kamiya N, Ogata K To be published -
  3. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.. Tahirov TH, Inoue-Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K Cell 104 755-67 (2001)

Quick links