1h59 Summary

pdbe.org/1h59
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COMPLEX OF IGFBP-5 WITH IGF-I

The structure was published by Zesaawski, W., Beisel, H.G., Kamionka, M., et al., Huber, R., Lang, K., and Holak, T.A., in 2001 in a paper entitled "The Interaction of Insulin-Like Growth Factor-I with the N-Terminal Domain of Igfbp-5" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN-LIKE GROWTH FACTOR IA and INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN-LIKE GROWTH FACTOR IA P05019 (49-118) (IGF1_HUMAN)search Homo sapienssearch < 90% 70 77%
B INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5 P24593 (60-112) (IBP5_HUMAN)search Homo sapienssearch < 90% 54 83%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P05019 (49 - 118) INSULIN-LIKE GROWTH FACTOR IA Homo sapiens
P24593 (60 - 112) INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Insulin-likesearch Insulin-like, subunit Esearch Insulin/IGF/Relaxin familysearch
B Growth factor receptor domainsearch Omega-AgatoxinVsearch Insulin-like growth factor binding proteinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P05019) extracellular spacesearch extracellular regionsearch growth factor activitysearch hormone activitysearch
B (P24593) extracellular regionsearch insulin-like growth factor bindingsearch regulation of cell growthsearch

Chain InterPro annotation
A Insulin-likesearch Insulin-like growth factor Isearch Insulin-like growth factorsearch Insulin familysearch Insulin, conserved sitesearch
B Insulin-like growth factor-binding protein, IGFBPsearch Insulin-like growth factor binding protein, N-terminalsearch Insulin-like growth factor binding proteinsearch Insulin-like growth factor binding protein 5search Insulin-like growth factor-binding protein family 1-6, chordatasearch