1h4l Summary

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STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX

The structure was published by Tarricone, C., Dhavan, R., Peng, J., Areces, L.B., Tsai, L.-H., and Musacchio, A., in 2001 in a paper entitled "Structure and Regulation of the Cdk5-P25(Nck5A) Complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.65 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 5 and CYCLIN-DEPENDENT KINASE 5 ACTIVATOR.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 5 Q00535 (1-292) (CDK5_HUMAN)search Homo sapienssearch 100% 292 95%
B CELL DIVISION PROTEIN KINASE 5 Not available
Homo sapienssearch 100% 292 95%
D CYCLIN-DEPENDENT KINASE 5 ACTIVATOR Q15078 (147-293) (CD5R1_HUMAN)search Homo sapienssearch < 90% 147 100%
E CYCLIN-DEPENDENT KINASE 5 ACTIVATOR Q15078 (147-293) (CD5R1_HUMAN)search Homo sapienssearch < 90% 147 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q00535 (1 - 292) CELL DIVISION PROTEIN KINASE 5 Homo sapiens
Q15078 (147 - 293) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q00535) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
D, E Cyclinsearch Cyclin A; domain 1search Cyclin-dependent kinase 5 activator proteinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q00535) protein kinase activitysearch acetylcholine receptor activator activitysearch ephrin receptor bindingsearch protein bindingsearch ATP bindingsearch protein serine/threonine kinase activitysearch ErbB-3 class receptor bindingsearch nucleotide bindingsearch tau-protein kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch ErbB-2 class receptor bindingsearch kinase activitysearch transferase activitysearch p53 bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch regulation of excitatory postsynaptic membrane potentialsearch positive regulation of receptor activitysearch apoptotic processsearch neuron migrationsearch neuron differentiationsearch response to woundingsearch cerebellar cortex developmentsearch protein autophosphorylationsearch regulation of synaptic plasticitysearch positive regulation of protein bindingsearch peptidyl-threonine phosphorylationsearch receptor catabolic processsearch calcium ion importsearch cerebellum developmentsearch neuron apoptotic processsearch motor neuron axon guidancesearch axonogenesissearch negative regulation of axon extensionsearch negative regulation of proteolysissearch nervous system developmentsearch regulation of cell cycle arrestsearch regulation of apoptotic processsearch cell deathsearch phosphorylationsearch cell proliferationsearch negative regulation of protein export from nucleussearch dendrite morphogenesissearch cell migrationsearch associative learningsearch exocytosissearch regulation of dendritic spine morphogenesissearch corpus callosum developmentsearch synapse assemblysearch positive regulation of protein kinase activitysearch peptidyl-serine phosphorylationsearch regulated secretory pathwaysearch negative regulation of cell cyclesearch forebrain developmentsearch response to cocainesearch receptor clusteringsearch synaptic transmission, dopaminergicsearch intracellular protein transportsearch cell divisionsearch embryo developmentsearch behavioral response to cocainesearch synaptic transmission, glutamatergicsearch cortical actin cytoskeleton organizationsearch synaptic vesicle endocytosissearch regulation of cell migrationsearch cell-matrix adhesionsearch positive regulation of neuron apoptotic processsearch oligodendrocyte differentiationsearch synaptic vesicle exocytosissearch negative regulation of protein ubiquitinationsearch positive regulation of calcium ion-dependent exocytosissearch sensory perception of painsearch rhythmic processsearch protein localization to synapsesearch axon guidancesearch telencephalon developmentsearch neuron projection developmentsearch regulation of postsynaptic membrane potentialsearch positive regulation of actin cytoskeleton reorganizationsearch synaptic transmissionsearch negative regulation of synaptic plasticitysearch nucleocytoplasmic transportsearch cerebellar cortex formationsearch hippocampus developmentsearch negative regulation of neuron deathsearch cell cyclesearch neuron projection morphogenesissearch Schwann cell developmentsearch blood coagulationsearch layer formation in cerebral cortexsearch central nervous system neuron developmentsearch serine phosphorylation of STAT3 proteinsearch negative regulation of transcription, DNA-templatedsearch cerebral cortex developmentsearch skeletal muscle tissue developmentsearch axon extensionsearch visual learningsearch positive regulation of protein targeting to membranesearch synapsesearch cytoplasmsearch lamellipodiumsearch axonsearch neuromuscular junctionsearch growth conesearch neuronal cell bodysearch nucleussearch membranesearch postsynaptic densitysearch cytosolsearch postsynaptic membranesearch dendritesearch cytoskeletonsearch filopodiumsearch cell projectionsearch perikaryonsearch cyclin-dependent protein kinase 5 holoenzyme complexsearch plasma membranesearch cell junctionsearch
D, E (Q15078) cyclin-dependent protein kinase 5 activator activitysearch cyclin-dependent protein kinase 5 holoenzyme complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
D, E Cyclin-dependent kinase 5 activatorsearch Cyclin-likesearch