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Structure and regulation of the CDK5-p25(nck5a) complex

X-ray diffraction
2.65Å resolution
PDB entry 1h4l coloured by chain, front view.
PDB entry 1h4l coloured by chain, side view.
PDB entry 1h4l coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant
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Multimeric state: hetero dimer
Accessible surface area: 19227.6 Å2
Buried surface area: 2827.28 Å2
Dissociation area: 1,413.64 Å2
Dissociation energy (ΔGdiss): 11.28 kcal/mol
Dissociation entropy (TΔSdiss): 12.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169443
Complex Portal ID: CPX-3142
Assembly 2
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Assembly Name: Cyclin-dependent protein kinase 5 holoenzyme complex, p35 variant
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Multimeric state: hetero dimer
Accessible surface area: 19043.48 Å2
Buried surface area: 2743.02 Å2
Dissociation area: 1,371.51 Å2
Dissociation energy (ΔGdiss): 10.69 kcal/mol
Dissociation entropy (TΔSdiss): 12.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169443
Complex Portal ID: CPX-3142

Macromolecules

Cyclin-dependent kinase 5
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.36 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00535 (Residues: 1-292; Coverage: 100%)
Gene names: CDK5, CDKN5, PSSALRE
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 5 in PDB entry 1h4l, assembly 1, front view.
Cyclin-dependent kinase 5 in PDB entry 1h4l, assembly 1, side view.
Cyclin-dependent kinase 5 in PDB entry 1h4l, assembly 1, top view.
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Cyclin-dependent kinase 5 activator 1, p25
Chains: D, E
Length: 147 amino acids
Theoretical weight: 17.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15078 (Residues: 147-293; Coverage: 48%)
Gene names: CDK5R, CDK5R1, NCK5A
Pfam: Cyclin-dependent kinase 5 activator protein
InterPro:
CATH: Cyclin-like
SCOP: Cyclin
Cyclin-dependent kinase 5 activator 1, p25 in PDB entry 1h4l, assembly 1, front view.
Cyclin-dependent kinase 5 activator 1, p25 in PDB entry 1h4l, assembly 1, side view.
Cyclin-dependent kinase 5 activator 1, p25 in PDB entry 1h4l, assembly 1, top view.
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