1h3i Summary

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CRYSTAL STRUCTURE OF THE HISTONE METHYLTRANSFERASE SET7/9

The structure was published by Wilson, J.R., Jing, C., Walker, P.A., et al., Blackburn, G.M., Gamblin, S.J., and Xiao, B., in 2002 in a paper entitled "Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE Q8WTS6 (52-344) (SETD7_HUMAN)search Homo sapienssearch < 90% 293 100%
B HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE Q8WTS6 (52-344) (SETD7_HUMAN)search Homo sapienssearch < 90% 293 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8WTS6 (52 - 344) HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Histone H3 K4-specific methyltransferase SET7/9 N-terminal domainsearch, Histone lysine methyltransferasessearch Histone H3 K4-specific methyltransferase SET7/9 N-terminal domainsearch, SET domainsearch SET domainsearch, MORN repeatsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (Q8WTS6) chromosomesearch regulation of transcription, DNA-templatedsearch histone lysine methylationsearch histone-lysine N-methyltransferase activitysearch

Chain InterPro annotation
A, B SET domainsearch MORN motifsearch Histone-lysine N-methyltransferase, SETsearch