1h3h Summary


Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain

The structure was published by Liu, Q., Berry, D., Nash, P., Pawson, T., Mcglade, C.J., and Li, S.S., in 2003 in a paper entitled "Structural Basis for Specific Binding of the Gads SH3 Domain to an Rxxk Motif-Containing Slp-76 Peptide: A Novel Mode of Peptide Recognition" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GRB2-RELATED ADAPTOR PROTEIN 2 and LYMPHOCYTE CYTOSOLIC PROTEIN 2.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GRB2-RELATED ADAPTOR PROTEIN 2 O89100 (263-322) (GRAP2_MOUSE)search Mus musculussearch < 90% 60 100%
B LYMPHOCYTE CYTOSOLIC PROTEIN 2 Q13094 (232-241) (LCP2_HUMAN)search Homo sapienssearch < 90% 11 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O89100 (263 - 322) GRB2-RELATED ADAPTOR PROTEIN 2 Mus musculus
Q13094 (232 - 241) LYMPHOCYTE CYTOSOLIC PROTEIN 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH3-domainsearch SH3 Domainssearch SH3 domainsearch
Chain InterPro annotation
A SH3 domainsearch