1h3e Summary


Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with wild-type tRNAtyr(GUA) and with ATP and tyrosinol

The structure was published by Yaremchuk, A., Kriklivyi, I., Tukalo, M., and Cusack, S., in 2002 in a paper entitled "Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely TYROSYL-TRNA SYNTHETASE and WILD-TYPE TRNATYR(GUA).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSYL-TRNA SYNTHETASE P83453 (1-432) (SYY_THET2)search Thermus thermophilus HB27search 100% 432 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P83453 (1 - 432) TYROSYL-TRNA SYNTHETASE Thermus thermophilus HB27

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P83453) Class I aminoacyl-tRNA synthetases (RS), catalytic domainsearch, Tyrosyl-tRNA synthetase (TyrRS), C-terminal domainsearch HUPssearch, Tyrosyl-Transfer RNA Synthetasesearch, Structural Genomics Hypothetical 15.5 Kd Protein In Mrca-pcka Intergenic Region; Chainsearch PF00579: tRNA synthetases class I (W and Y)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P83453) tyrosine-tRNA ligase activitysearch aminoacyl-tRNA ligase activitysearch nucleotide bindingsearch ATP bindingsearch RNA bindingsearch ligase activitysearch cytoplasmsearch tRNA aminoacylation for protein translationsearch tyrosyl-tRNA aminoacylationsearch translationsearch

Chain InterPro annotation
A Aminoacyl-tRNA synthetase, class Icsearch Tyrosine-tRNA ligasesearch RNA-binding S4 domainsearch Rossmann-like alpha/beta/alpha sandwich foldsearch Tyrosine-tRNA ligase, bacterial-typesearch Tyrosine-tRNA ligase, bacterial-type, type 2search