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EBI PDBe PDBeView

PDBe Entry: 1h39 view

STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Summary
Header ISOMERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.8 Å, R-factor: 22.5%, Free R-factor: 25.5%, Spacegroup: P 32 2 1
Released 21/08/2003, deposition: 24/08/2002, last revision: 24/02/2009
Authors Lenhart, A.search; Reinert, D.J.search; Weihofen, W.A.search; Aebi, J.D.search; Dehmlow, H.search; Morand, O.H.search; Schulz, G.E.search
Primary citation Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.MED.CHEM.search vol:46, pag:2083 (2003) [PubMed ID 12747780 ]search
Keywords ISOMERASEsearch, CHOLESTEROL BIOSYNTHESISsearch, INHIBITORsearch, INTERACTIONSsearch, OXIDOSQUALENE CYCLASEsearch, MONOTOPIC MEMBRANE PROTEINsearch
EC 5.4.99.17 ExPASy BRENDA search (A B C)
Organism Alicyclobacillus acidocaldarius 405212search(A B C)
UniProt Squalene--hopene cyclase (EC 5.4.99.17) P33247search (A B C)
Solvent A, B, C
Related entries 1gsz, 1h35, 1h36, 1h37, 1h3a, 1h3b, 1h3c, 1sqc, 2sqc, 3sqc
Polymers
Id Name Type UniProt Residues Observed
A, B, C SQUALENE--HOPENE CYCLASE Protein P33247 (SQHC_ALIAD)search
 631 98%
Heterogens
Id Name Ligands
A, B, C (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE C8E search
A, B, C ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE R03 search
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