1h1r Summary

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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6086

The structure was published by Davies, T.G., Bentley, J., Arris, C.E., et al., Tucker, J.A., Wang, L., and Whitfield, H.J., in 2002 in a paper entitled "Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 303 98%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 303 98%
B CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%
D CYCLIN A2 P20248 (175-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 258 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (175 - 432) CYCLIN A2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P24941) protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch nucleotide bindingsearch metal ion bindingsearch histone kinase activitysearch transferase activitysearch nucleoplasmsearch cytoskeletonsearch nucleussearch centrosomesearch Cajal bodysearch cytosolsearch endosomesearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch Y chromosomesearch cytoplasmsearch microtubule organizing centersearch chromosome, telomeric regionsearch condensed chromosomesearch transcription factor complexsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch meiotic nuclear divisionsearch blood coagulationsearch cell cyclesearch histone phosphorylationsearch protein phosphorylationsearch G1/S transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch potassium ion transportsearch phosphorylationsearch centrosome duplicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch regulation of gene silencingsearch mitotic nuclear divisionsearch DNA repairsearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to DNA damage stimulussearch mitotic cell cyclesearch cell divisionsearch cellular response to nitric oxidesearch Ras protein signal transductionsearch positive regulation of cell proliferationsearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch
B, D (P20248) protein kinase bindingsearch nucleussearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cell cyclesearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch